Registration Dossier
Registration Dossier
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EC number: 274-407-9 | CAS number: 70210-10-5
Endpoint summary
Administrative data
Description of key information
The substance is non-irritating to the skin and eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Local changes induced by the substance at the site of contact, namely skin and eye, were evaluated irrespective of whether the substance may become systemically available. Skin and eye irritation of the substance were tested on rabbits by topical application and instillation, respectively.
As for the dermal application, very slight erythema and oedema were noted. The incidence of these signs tend to decrease over 72 hours of observation. The 14 -day observation was not performed.
As for the eye instillation, no effects on cornea, iris and conjuctivae chemosis were seen throughout the study period, even if the eye was not rinsed.
Under the test conditions, during the observation period, the substance did not induce systemic toxicity nor mortality.
Justification for classification or non-classification
The substance is not classified according to the CLP Regulation (EC 1272/2008).
As for skin irritation, the mean scores for erythema and oedema over 24 h, 48 h (not measured, assumed to be equal to the highest value between 24 and 72 h) and 72 h are below the threshold for classification, i.e. 2.3, in all animals tested.
As for eye irritation, the averaged scores over 24, 48 and 72 hours for all animals are below the thresholds for classification, i.e. 1 for cornea and iris, and 2 for conjuctivae redness and chemosis.
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