Registration Dossier
Registration Dossier
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EC number: 207-997-3 | CAS number: 504-63-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Relevant physical-chemical properties data are available which can be used to estimate toxicokinetic behaviour in mammalian systems. The substance has a log Kow of -0.71, a vapor pressure of 3.9 Pa, is water soluble at > 1000 g/L, and is readily biodegraded. These properties are indicators that the substance will be rapidly absorbed by the oral and inhalation routes of exposure and be rapidly metabolized to carbon dioxide and water. Although formal toxicokinetic work by standard test guidelines is not available, there are several reports in the literature that collectively support a rapid metabolism and the transient formation of specific aldehyde, semi-aldehyde, and acid metabolites.
Specifically, the proposed metabolic pathway for this substance follows that for other simple alcohols where alcohol and aldehyde dehydrogenase enzymes sequentially break down this substance to acids used in intermediary metabolism. PDO is metabolized to 3-hydroxypropionaldehyde, malondialdehyde or 3-hydroxypropionic acid, malonic semi-aldehyde, malonic acid, and ultimately carbon dioxide and water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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