Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 June 1991 - 2 July 1991
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
other: FDA guideline: Technical Assistance Document 3.06 (March 1987)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
other: Capillary method with photocell detection

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): T001624
- Physical state: solid
- Appearance: white powder
- CAS: 132961-05-8
- Molecular formula: C23H28F2N4O2
- Molecular weight: 430.5 g/mol
Specific details on test material used for the study:
- Batch: RT001624BEA011
- Purity: 99.1% (HPLC purity)

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
194.6 °C
Decomposition:
no
Remarks on result:
other: There was no information on decomposition mentioned in the report

Any other information on results incl. tables

Preliminary test

The observed melting point of the reference substance using the Reichert Heizbank is about 463 K (190°C).

The observed melting point of the test substance using the Reichert Heizbank is about 468 K (195°C).

Determination of the melting point using the Mettler apparatus

The mean melting point of the reference substance is 464.5 K (191.3°C) and the mean melting point of the test substance is 467.7 K (194.6°C).

Applicant's summary and conclusion

Conclusions:
The melting point of the test substance was determined via Capillary method with photocell detection and is determined to be 467.7K (194.6°C).