Registration Dossier
Registration Dossier
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EC number: 813-843-1 | CAS number: 54884-93-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,3-bis(methylthio)propan-1-ol
- EC Number:
- 813-843-1
- Cas Number:
- 54884-93-4
- Molecular formula:
- C5H12OS2
- IUPAC Name:
- 1,3-bis(methylthio)propan-1-ol
- Test material form:
- liquid
- Details on test material:
- - Analytical purity: 93 %
- Lot/batch No.: AK16-008
Constituent 1
Test animals / tissue source
- Species:
- cattle
- Details on test animals or tissues and environmental conditions:
- Freshly isolated bovine cornea (at least 9 month old donor cattle)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 0.75 mL
- Duration of treatment / exposure:
- 10 min
- Duration of post- treatment incubation (in vitro):
- 2 h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- 11.31
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- In conclusion, according to the current study and under the experimental conditions reported, MMP-MC is not serious eye damaging UN GHS Category 1 but no prediction for eye irritation can be made (GHS).
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