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EC number: 701-133-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 3 Aug - 5 Aug 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles (analytical purity of test substance not specified).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- A single epicutaneous application (occlusive) is done on the back of at least 12 human volunteers to assess the skin irritation potential of the substance. Readings and scoring are peformed 30 min and 24 hours after patch removal.
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Name of test material (as cited in study report): Ester of Isononanoic acid with Isononanol
- Physical state: colorless oil
- Analytical purity: not specified
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 12
- Sex: 5 males and 7 females
- Age: 21-64 - Ethical approval:
- confirmed, but no further information available
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- About 0.02 mL of the product (saturating a disc of filter paper placed in the patch) was applied once, on about 50 mm² of skin on the upper back of each volunteer and kept in contact with the skin for 24 h.
- two control cups are always applied: 1) 1% of sodium lauryl sulfate; 2) distilled water - Examinations:
- SCORING SYSTEM FOR SKIN REACTIONS:
Erythema (Redness)
0 None
1 Doubtful pinkness of all the site or clearly visible pinkness of any part of the site
2 Clear pinkness of all the site or redness of only a part of the site
3 Clear redness of all the site or intensive redness of part of the site
4 Intensive redness and/or burn aspect
Edema
0 None
1 Doubtful swelling of all the site or slight swelling of only part of the site
2 Slight swelling of all the site or clear swelling of only a part of the site
3 Clear swelling of all the site or strong swelling of only a part of the site
4 Strong swelling of all the site, even extending beyond the site
Vesicles
0 None
1 Few small vesicles (< 1mm diameter), on less than ¼ of the site
2 Small vesicles (< 1mm diameter), on about ¼ of the site
3 Small vesicles (< 1mm diameter), on ¼ to ½ of the site
4 Some small vesicles (< 1 mm diameter), on more than half of the site, or some large vesicles ( 1 to 2 mm diameter)
Cutaneous Dryness
0 None
1 Dullness, matness of all the site or powdery aspect of only a part of the site
2 Powdery aspect of all the site or some scaling/flaking of only a part of the site
3 Scaling/flaking of all the site or thick scales/flakes on only a part of the site
4 Some thick scales/flakes on all the site with possibly deep cracking
Wrinkling
0 None
1 Slight wrinkling of all the site or clear wrinkling of only a part of the site
2 Distinct wrinkling of all the site or well-developed wrinkling of only a part of the site
3 Well-developed wrinkling into ridges anf throughs of all the site or severe wrinkling of only a part of the site
4 Wrinkling forms deep throughs and high ridges
Glazing
0 None
1 All site slightly shiny or only part of the site clearly shiny
2 All site clearly shiny or glossiness of only a part of the site
3 Clear glossiness of all the site or very glossy aspect of only a part of the site
4 All site very glossy and/or highly reflective
Results and discussion
- Clinical signs:
- Negative control site: no reactions for all volunteers; Positive control site: slight to clear reactions on 11 sites, no reaction on one subject; Test product site: no reactions observed on 10 subjects, very slight erythema for 2 subjects. The one subject which did not show skin reactions for the positive control was excluded from the study.
- Results of examinations:
- The irritation index was calculated from the 11 subjects who were retained. The scores attributed allowed to obtain an irritation index of 0.02.
Applicant's summary and conclusion
- Conclusions:
- Not irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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