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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
(1992)
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
(1989)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
3.33
Temp.:
25 °C
pH:
7
Remarks on result:
other: 95 % confidence limits: (3.14 - 3.52)
Details on results:
The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.

The log Pow value of the test compound was calculated from its log k' and the calibration line to be (at 25 °C):

 Compound           retention time [min]  log k' log Pow 
   1.  2.  3.  mean    
 Test item  3.68  3.69  3.69  3.69  0.40

 3.33

Conclusions:
The partition coefficient of the substance was determined at log Pow = 3.33 at 25°C and pH7.
Executive summary:

The partition coefficient of the substance was determined according to EU Testing Guideline A.8 "Determination of the partition cofficient, HPLC method", based on OECD guideline 117. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values. The test item showed a result of log Pow = 3.33 (95 % confidence limits 3.14 - 3.52), which indicates considerable lipophilicity.

Description of key information

The partition coefficient of the substance was determined at log Pow  = 3.33 at 25°C and pH7.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.33
at the temperature of:
25 °C

Additional information