Registration Dossier
Registration Dossier
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EC number: 202-440-0 | CAS number: 95-68-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitising potential ofm-Xylidine was tested in one Local Lymph Node Assay (LLNA) according to OECD test guideline 429. In this assay S.I. of 1.83, 2.07 and 2.65 were determined with the test item at concentrations of 2.5%, 5% and 10% in Propylene glycol.
In this assay no EC3 value could be calculated since all S.I. values were below 3.
Migrated from Short description of key information:
m-Xylidines has been tested in one Local Lymph Node Assay to assess the sensitising potential of the test item. In this assay Stimulation Indices (S.I.) obtained with test concentrations up to 10% in Propylene glycol were below 3.
Justification for classification or non-classification
m-Xylidine did not show skin sensitizing properties in the LLNA study according to the current OECD guidelines. Allergic skin reactions or case reports of acute contact dermatitis to m-Xylidine have not been described in the literature. Therefore, the substance does not have to be classified as a skin sensitizer.
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