Registration Dossier
Registration Dossier
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EC number: 202-440-0 | CAS number: 95-68-1
Specific investigations: other studies
Administrative data
- Endpoint:
- methaemoglobinaemia
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, no OECD technical guidelines, report is rather brief, essential details on materials and methods are missing
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 938
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method of Evelyn and Malloy was used, see reference.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- 2,4-xylidine
- EC Number:
- 202-440-0
- EC Name:
- 2,4-xylidine
- Cas Number:
- 95-68-1
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2,4-dimethylaniline
- Details on test material:
- Refer to endpoint: Acute toxicity: oral, Lindstrom et al. 1969
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - 5 animals were treated with the test compound
- 5 animals served as control
Administration / exposure
- Route of administration:
- other: injection into femural vein
- Vehicle:
- other: saline
- Details on exposure:
- - animals were anesthetized with sodium pentobarbital and were then given maximum tolerated doses of the hydrochlorides of each test material in 1mL of saline by injection into the femoral vein
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- One single injection, sample were taken at different time points after single exposure
- Frequency of treatment:
- One single injection, sample were taken at different time points after single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Maximum tolerated dose in 1mL of saline
Basis:
nominal conc.
- Control animals:
- yes, concurrent vehicle
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The xylidines are not very effective methemoglobin formers. Of this group of amines 2,4-xylidine is the most effective. It produces maximum methemoglobin at 1hr as compared to 3hrs for 2,5- and 2,6-xylidine.
- Executive summary:
No classification has to be made based on these findings,
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