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EC number: 807-113-1
CAS number: 3709-71-5
HFP kinetic dimer is volatile (VP, 34700 Pa at 20 °C) and has a water
solubility of 649 µg/L at 22.3 °C. Its experimentally determined Henry's
Law constant is 1.40E+07 Pa m³/mol (138 atm m³/mole) at 22 °C. HFP
kinetic dimer is difficult to retain in aqueous solution, and the key
fish, daphnia and algae toxicity studies used entirely closed systems
without headspace throughout the test to obtain consistent
concentrations, with analytical confirmation of test substance
concentration. Test vessels at the highest test substance concentration
intentionally contained a small amount of undissolved test material,
although lower concentrations did not. Measurable concentrations of HFP
kinetic dimer were present throughout the exposure period at higher
concentrations, although concentrations fell below the limit of
quantitation at lower concentrations. Loss of quantitation did not
affect the results of any key study. The most sensitive species was
Daphnia magna, for which 50% effect was exceeded in the dilution series.
In the algae test, the 50% effect threshold was crossed between the two
highest concentrations, with the aforementioned undissolved material
present at the highest level. Saturated solutions did not attain 50%
effect in the fish.
Two additional studies of fish toxicity were deemed not reliable. All of
the key studies were performed in accordance with
internationally-accepted test guidelines and Good Laboratory Practice
(GLP) standards. Therefore, the studies are reliable, and the results
suitable for purposes of Risk Assessment, Classification & Labeling, and
The primary fate of HFP kinetic dimer is expected to be photolysis to
HF, TFA and iPFBA. These acids are highly soluble and are expected to
reside ultimately in the aquatic compartment. HF and TFA are subjects of
existing risk assessments.
Table 1, HFP kinetic dimer aquatic toxicity results
> 12 µg/L ¹
>5 mg/L ²
350 - 500 mg/L
Pimephales promelas ³
<1.0 mg/L ²
>1.0 mg/L ²
48 -hour EC50
14 µg/L ¹
35 µg/L ¹
17 µg/L ¹
3.3 µg/L ¹
1, Measured concentration
2, Nominal concentration
3, The first result is of direct addition of HFP dimer, the second result is of a water accomodated fraction
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