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EC number: 203-536-5
CAS number: 107-95-9
-A primary skin irritation study in rabbits was conducted with beta-alanine (4 hour-exposure, according to OECD TG 404, Draize scheme; GLP): beta-alanine is not a skin irritant.-In an eye irritation study (equivalent to OECD TG 405; GLP, Draize score): β-alanine is not irritating to the eyes
A GLP study was
performed to assess the irritation potential of beta-alanine to the skin
of 2 New Zealand White rabbits. The method was designed to meet the
following requirements: OECD Guidelines for the Testing of Chemicals No.
404 “Acute Dermal Irritation/Corrosion” (adopted 24 April 2002); Method
B4 Acute Toxicity (Skin Irritation) of Commission Regulation (EC)
No. 440/2008. A single 4-hour semi-occluded application of the test
material to the intact skin of two rabbits produced no evidence of skin
irritation. No corrosive effects were noted. The test material produced
erythema score and oedema scores of 0.0 and was classified as
non-irritant to rabbit skin according to the Draize classification
In order to assess the
irritancy potential of the test material an in vivo eye
irritation test was performed on 2 New Zealand White rabbits. The study
was method was designed to meet the requirements of the following: OECD
Guidelines for the Testing of Chemicals No. 405 “Acute Eye
Irritation/Corrosion” (adopted 24 April 2002); Method B5 Acute Toxicity
(Eye Irritation) of Commission Regulation (EC) No. 440/2008. A volume of
0.1mL of the test material was placed into the conjunctival sac of the
right eye, formed by gently pulling the lower lid away from the eyeball. The
application of the test material to the non-irrigated eye of two rabbits
produced moderate conjunctival redness (Draize Score 1 for 1 animal and
2 for the second animal), which was reversible with 48 hours.
On the basis of the test results, beta-alanine has not to be
classified for skin/eye irritation according to DSD and CLP criteria.
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