Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-536-5 | CAS number: 107-95-9
Endpoint summary
Administrative data
Description of key information
-A primary skin irritation study in rabbits was conducted with beta-alanine (4 hour-exposure, according to OECD TG 404, Draize scheme; GLP): beta-alanine is not a skin irritant.
-In an eye irritation study (equivalent to OECD TG 405; GLP, Draize score): β-alanine is not irritating to the eyes
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A GLP study was performed to assess the irritation potential of beta-alanine to the skin of 2 New Zealand White rabbits. The method was designed to meet the following requirements: OECD Guidelines for the Testing of Chemicals No. 404 “Acute Dermal Irritation/Corrosion” (adopted 24 April 2002); Method B4 Acute Toxicity (Skin Irritation) of Commission Regulation (EC) No. 440/2008. A single 4-hour semi-occluded application of the test material to the intact skin of two rabbits produced no evidence of skin irritation. No corrosive effects were noted. The test material produced erythema score and oedema scores of 0.0 and was classified as non-irritant to rabbit skin according to the Draize classification scheme.
In order to assess the irritancy potential of the test material an in vivo eye irritation test was performed on 2 New Zealand White rabbits. The study was method was designed to meet the requirements of the following: OECD Guidelines for the Testing of Chemicals No. 405 “Acute Eye Irritation/Corrosion” (adopted 24 April 2002); Method B5 Acute Toxicity (Eye Irritation) of Commission Regulation (EC) No. 440/2008. A volume of 0.1mL of the test material was placed into the conjunctival sac of the right eye, formed by gently pulling the lower lid away from the eyeball. The application of the test material to the non-irrigated eye of two rabbits produced moderate conjunctival redness (Draize Score 1 for 1 animal and 2 for the second animal), which was reversible with 48 hours.
Justification for classification or non-classification
On the basis of the test results, beta-alanine has not to be classified for skin/eye irritation according to DSD and CLP criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
