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Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 03, 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed according to OECD guidelines and according to GLP principles.
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
Deviations:
no
Principles of method if other than guideline:
ISO Standard 8192, Water Quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation (2007).
GLP compliance:
yes
Analytical monitoring:
no
Test organisms (species):
activated sludge of a predominantly domestic sewage
Test type:
other: aerobic
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Key result
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Key result
Duration:
3 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Comments:
Under the conditions of this present test, the test
substance was not toxic to waste water (activated sludge)
bacteria at the loading rate of 100 mg/l, the regulatory
limit concentration.

Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of this present test, Reaction products of Fatty acids, C16-18 and C18-unsatd. and reaction mass of 1,3-alkanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-heteromonocycle-5,5-dimethanol was not toxic to waste water (activated sludge) bacteria at the loading rate of 100 mg/l, the regulatory limit concentration.

Description of key information

The study was performed according to OECD Guideline 209 and GLP principles.

Key value for chemical safety assessment

EC50 for microorganisms:
100 mg/L
EC10 or NOEC for microorganisms:
100 mg/L

Additional information

The respiration rate of activated sludge was investigated according to OECD test guideline 209. The sludge was exposed to Radia 7853 with a contact time of 3 hours, at a final loading rate of 100 mg/l. No significant inhibition of respiration rate of the sludge was recorded at the loading rate of 100 mg/l, thus no further testing was required. Hence, the EC50 of Rqadia 7853 was >100 mg/l (nominal) and the NOEC was determined to be 100 mg/l.