Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

The registered substance is hydrolytically stable at pH from 5 to 12 but unstable at pH lower than 5. The registered substance is a macrocyclic compound containing three potentially acid sensitive functionalities:

- The epoxide function of a trisubtituted double bond: in acidic conditions and already at pH 5, the epoxide could open up generating an alcohol and a tertiary carbocation (stabilized intermediate) which could then be intercepted by water to form an alcohol. Globally the epoxide has been transformed to a diol.

- The two trisubstituted double bonds in the molecule: in acidic media an hydration reaction could take place and would lead to tertiary alcohol.

As a conclusion, the registered substance in acidic media will hydrolyze to give poly-hydroxylated product.

Additional information