Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 14 to 22, 2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Validation applies, with minor restrictions due to technical inaccuracies.
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
adopted by the Council on 13th April 2004
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
Swiss GLP compliance programme (inspected on November 15 and 16, 2006/ signed on March 29, 2007)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.05
Temp.:
30 °C
pH:
6
Remarks on result:
other:
Remarks:
Partition coefficient: 1.12 X 10^5
Details on results:
Partition coefficient of sample:
Mean log10Pow: 5.05
Partition coefficient: 1.12 x 10^5

Testing was carried out at neutral pH.

Preliminary estimate

Approximate Pow: 5.25 x 105

Log10Pow estimate: 5.72

 

Definitive test

Regression parameters: log Pow = 5.8593 x log k + 3.2996 (r = 0.9788)

 

Table 4.7/1:Partition coefficient of sample

 

 

RT 1

RT 2

RT 3

RT 4

RT 5

Mean RT

STD

 

CV%

 

K

 

Log10K

 

Log10Pow

 

 

(min)

(min)

(min)

(min)

(min)

(min)

(To) Dead time

3.97

3.97

3.97

3.97

3.97

3.97

0.00

0.00%

0.00

-

-

Test item

11.87

11.87

11.87

11.87

11.87

11.87

0.00

0.00%

1.990

0.299

5.05

 

RT = Retention time

Mean RT = = Mean retention time

STD = standard deviation

CV= coefficient of variation

Mean log10Pow: 5.05

Partition coefficient: 1.12 x 105

Conclusions:
The test substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow >4).
Executive summary:

The partition coefficient of the test substance was measured under GLP according to the OECD 117/EU A8 guideline, HPLC method.The system was calibrated with 6 reference substances, and the result for the sample was interpolated from the linear regression.

Partition coefficient (log Pow) of the test substance has been determined to be 1.12 x 105, Log10Pow 5.05.

Description of key information

The test substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (>4).

It should also be taken into account for PBT assessment (logKow > 4.5).

Key value for chemical safety assessment

Log Kow (Log Pow):
5.05
at the temperature of:
30 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result is retained as key data for purpose of CSA.