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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 14 to 22, 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
adopted by the Council on 27th July 1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
other: BS4633: Method for the Determination of Crystallizing Point
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
Swiss GLP compliance programme (inspected on November 15 and 16, 2006/ signed on March 29, 2007)
Type of method:
method to determine freezing temperature
Melting / freezing pt.:
< -20 °C
Decomposition:
no
Remarks on result:
other: < 253 ± 0.5 K

Table 4.2/1: Determinations 1 and 2

Determination 1

Time (s)

Temperature (K)

Determination 2

Time (s)

Temperature (K)

0

299

0

299

30

296

30

295

60

292

60

291

90

289

90        

289

120

285

120

288

150

283

150

286

180

281

180

283

210

277

210

282

240

272

240

279

270

270

270

278

300

268

300

277

330

266

330

275

360

265

360

274

390

263

390

273

420

261

420

271

450

259

450

272

480

257

480

271

510

255

510

271

540

253

540

271

570

252

570

270

600

251

600

271

630

251

630

261

660

250

660

260

690

250

690

260

720

250

720

259

750

249

750

259

780

-

780

258

810

-

810

256

840

-

840

256

870

-

870

255

900

-

900

253

930

-

930

252

960

-

960

251

990

-

990

250

1020

-

1020

250

 

Observations: Test substance remained unchanged in appearance during cooling.

The freezing temperature of test substance has been determined to be < -20 ± 0.5 °C (< 253 ± 0.5 K).

Conclusions:
The freezing point of test item was stated as < - 20 °C (< 253.15 K). No further testing is required.
Executive summary:

The freezing point of the test substance was determined under GLP according to OECD 102 / EU A1 guideline,using a procedure based on BS4633: Method for the Determination of Crystallizing Point.The determination was carried out in duplicate and no freezing was observed at the minimum test temperature.

 

The freezing temperature of test substance has been determined to be less than < 253 ± 0.5 K (< -20 ± 0.5 °C).

Description of key information

Freezing point  < -20 ± 0.5 °C (<253 ± 0.5 K)

No further testing required.

Key value for chemical safety assessment

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. As no crystallisation was observed down to -20°C, the result is expressed as a limit value, and cannot be retained as key data for purpose of CSA.