α,α-dimethylphenethyl butyrate

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in mammalian cells

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 476 (In Vitro Mammalian Cell Gene Mutation Test)

GLP compliance:

yes (incl. QA statement)

Type of assay:

other: Cell Gene Mutation Test

Test material

Test material information

Constituent 1

Reference substance name:

α,α-dimethylphenethyl acetate

EC Number:

205-781-3

EC Name:

α,α-dimethylphenethyl acetate

Cas Number:

151-05-3

Molecular formula:

C12H16O2

IUPAC Name:

1,1-dimethyl-2-phenylethyl acetate

Test material form:

solid

Results and discussion

Test results

Key result

Species / strain:

Chinese hamster Ovary (CHO)

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

cytotoxicity

Remarks:

was slightly toxic at the concentration of 180 μg/mL