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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Study period:
09/1964
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964

Materials and methods

Principles of method if other than guideline:
Method: other: Farbenfabrik Bayer AG
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
IUCLID4 Test substance: other TS: "pure" cyclododecanol, no further information

Test animals

Species:
rat

Administration / exposure

Vehicle:
other: acetone + vegetable oil (1:10)
Doses:
500 mg/kg bw
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 500 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
MORTALITY: none
CLINICAL SIGNS: none

Applicant's summary and conclusion

Conclusions:
CL-Freetext:
Significant dermal resorption of the test substance was not observed.