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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS
Author:
G. K. LLOYO, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES
Year:
1977
Bibliographic source:
Food and Cosmetics Toxicology Vol. 15, pp. 607-610. Pergamon Press 1977.
Reference Type:
review article or handbook
Title:
Resorcinol
Author:
World Health Organization (WHO).
Year:
2006
Bibliographic source:
The United Nations Environment Programme (UNEP); International Programme on Chemical Safety (IPCS); 2006

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: According to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)
Principles of method if other than guideline:
An eye irritation study of Resorcinol (CAS No: 108-46-3) was conducted on eye of three New Zealand White rabbits according to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): Resorcinol
- Molecular formula: C6H6O2
- Molecular weight: 110.1114 g/mol
- Substance type: organic
- Physical state: solid
-Smiles: c1c(cccc1O)O
-InChI: 1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
Specific details on test material used for the study:
- Name of test material (as cited in study report): Resorcinol
- Molecular formula: C6H6O2
- Molecular weight: 110.1114 g/mol
- Substance type: organic
- Physical state: solid
-Smiles: c1c(cccc1O)O
-InChI: 1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
2.5%
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
24 hours
Number of animals or in vitro replicates:
3 rabbits
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The eyes of all the rabbits were irrigated with 50 ml of lukewarm (37°C)
water, 10 sec after instillation of the test material

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
0
Reversibility:
fully reversible within: 24 hours
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The chemical caused only mild conjunctival inflammation, disappearing within 24 h post-application.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Resorcinol (CAS No: 108-46-3) was considered to be not irritating to eyes of three New Zealand White rabbits.
Executive summary:

An eye irritation study of Resorcinol (CAS No: 108-46-3) was conducted on  three New Zealand White rabbits according to the United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)

 

The installation of 2.5% (w/v) solution of resorcinol into the eyes (rinsing 10 s after application) produced only mild conjunctival inflammation which was disappeared within 24 h post-application.

 

Since the ocular lesions were not persisted, the chemical Resorcinol (CAS No: 108-46-3) was considered to be not irritating to eyes of three New Zealand White rabbits.