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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute Dermal toxicity of Resorcinol (108-46-3).
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
Reference Type:
other:
Title:
Acute Dermal toxicity of Resorcinol (108-46-3).
Author:
Hazardous Substances Data Bank
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2017.
Reference Type:
review article or handbook
Title:
Acute Dermal toxicity of Resorcinol.
Author:
World Health Organization
Year:
2006
Bibliographic source:
World Health Organization, International Programme on Chemical Safety (IPCS), United Nations Environment Programme (UNEP), 2006
Reference Type:
secondary source
Title:
Reports by the Scientific Committee on Cosmetology on the Use of Certain Hair Dyes
Author:
European Commission (EC) - Scientific Committee on Cosmetology (SCC)
Year:
1993
Bibliographic source:
Opinion of the Scientific Committee on Cosmetology (11/86 - 10/90), European Commission (EC) - Scientific Committee on Cosmetology (SCC), 1993.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute Dermal toxicity of Resorcinol (108-46-3) in Rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1114 g/mole
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report): Resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1114 g/mole
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
male

Administration / exposure

Type of coverage:
open
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
24 h
Doses:
1000, 2000 and 3360 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animal was observed for clinical signs, body weight and Gross pathology.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3 360 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50% morality was observed at 3360 mg/kg bw
Clinical signs:
At 1000 mg/kg body weight – Animals were experienced slight hyperkeratosis and moderate to severe irritation after 24 h of exposure.
Body weight:
Body weight loss was observed at 1000 mg/kg.
Gross pathology:
At ≥2000 mg/kg body weight - skin necrosis but no gross lesions was seen in treated rabbits.
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 3360 mg/kg bw, when male rabbits were treated with Resorcinol by topically application for 24 hours.
Executive summary:

The acute dermal toxicity study was conducted by using Resorcinol in male rabbits at the concentration of 1000, 2000 and 3360 mg/kg bw for 24 h applied by topically. Animals were observed for clinical signs, body weight and Gross pathology. 50% morality was observed in rabbits at 3360 mg/kg along with clinical signs such as - At 1000 mg/kg body weight – Animals were experienced slight hyperkeratosis and moderate to severe irritation after 24 h of exposure. At ≥2000 mg/kg body weight - skin necrosis was seen in treated rabbits.Body weight loss was observed at 1000 mg/kg. No gross lesions were observed at 1000 mg/kg body weight. Therefore, LD50 was considered to be 3360 mg/kg bw, when male rabbits were treated with Resorcinol by topically application for 24 hours.