4,4'-dihydroxy-7,7'-iminodi(naphthalene-2-sulphonic acid)

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Data is from authoritative database

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Acute Dermal toxicity of Resorcinol (108-46-3).

Author:

U.S. National Library of Medicine

Year:

2017

Bibliographic source:

ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017

Reference 2

Reference Type:

other:

Title:

Acute Dermal toxicity of Resorcinol (108-46-3).

Author:

Hazardous Substances Data Bank

Year:

2017

Bibliographic source:

HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2017.

Reference 3

Reference Type:

review article or handbook

Title:

Acute Dermal toxicity of Resorcinol.

Author:

World Health Organization

Year:

2006

Bibliographic source:

World Health Organization, International Programme on Chemical Safety (IPCS), United Nations Environment Programme (UNEP), 2006

Reference 4

Reference Type:

secondary source

Title:

Reports by the Scientific Committee on Cosmetology on the Use of Certain Hair Dyes

Author:

European Commission (EC) - Scientific Committee on Cosmetology (SCC)

Year:

1993

Bibliographic source:

Opinion of the Scientific Committee on Cosmetology (11/86 - 10/90), European Commission (EC) - Scientific Committee on Cosmetology (SCC), 1993.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute Dermal toxicity of Resorcinol (108-46-3) in Rabbit.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Resorcinol

Cas Number:

Resorcinol

Molecular formula:

C6H6O2

IUPAC Name:

Resorcinol

Details on test material:

- Name of test material (as cited in study report): Resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1114 g/mole
- Substance type: Organic

Specific details on test material used for the study:

- Name of test material (as cited in study report): Resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1114 g/mole
- Substance type: Organic

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

male

Administration / exposure

Type of coverage:

open

Vehicle:

not specified

Details on dermal exposure:

not specified

Duration of exposure:

24 h

Doses:

1000, 2000 and 3360 mg/kg

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

- Other examinations performed: Animal was observed for clinical signs, body weight and Gross pathology.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

3 360 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50 % mortality observed

Mortality:

50% morality was observed at 3360 mg/kg bw

Clinical signs:

other: At 1000 mg/kg body weight – Animals were experienced slight hyperkeratosis and moderate to severe irritation after 24 h of exposure.

Gross pathology:

At ≥2000 mg/kg body weight - skin necrosis but no gross lesions was seen in treated rabbits.

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

LD50 was considered to be 3360 mg/kg bw, when male rabbits were treated with Resorcinol by topically application for 24 hours.

Executive summary:

The acute dermal toxicity study was conducted by using Resorcinol in male rabbits at the concentration of 1000, 2000 and 3360 mg/kg bw for 24 h applied by topically. Animals were observed for clinical signs, body weight and Gross pathology. 50% morality was observed in rabbits at 3360 mg/kg along with clinical signs such as - At 1000 mg/kg body weight – Animals were experienced slight hyperkeratosis and moderate to severe irritation after 24 h of exposure. At ≥2000 mg/kg body weight - skin necrosis was seen in treated rabbits.Body weight loss was observed at 1000 mg/kg. No gross lesions were observed at 1000 mg/kg body weight. Therefore, LD50 was considered to be 3360 mg/kg bw, when male rabbits were treated with Resorcinol by topically application for 24 hours.