Registration Dossier
Registration Dossier
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EC number: 222-123-0 | CAS number: 3353-69-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Bacterial reverse mutation assay: negative with and without metabolic
activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA
1537 or TA 102 (OECD 471) (Eurofins, 2015).
Cytogenicity in mammalian cells: negative with and without metabolic
activation in Chinese hamster lung fibroblasts V79 (OECD 473) (Eurofins
Biopharma 2016).
Mutagenicity in mammalian cells: negative with and without metabolic activation in mouse lymphoma L5178Y cells (OECD 490) (Eurofins, 2016)
The studies were conducted according to appropriate OECD test
guidelines, and in compliance with GLP.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
1,2 -Bis[dichloro(methyl)silyl]ethane has been tested for mutagenicity to bacteria, in a study which was conducted according to the OECD TG 471, compliant with GLP (Eurofins, 2015). No evidence of a test-substance related increase in the number of revertants was observed with or without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 or TA 102 in the initial or the repeat experiments up to limit concentrations. Appropriate positive, solvent and negative controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
1,2-Bis[dichloro(methyl)silyl]ethane has been tested for ability to cause chromosome aberrations in Chinese hamster lung fibroblasts V79 according to OECD TG 473 and under GLP (Eurofins, 2016). No increase in the number of cells with aberrations was observed either with or without metabolic activation up to cytotoxic or precipitating concentrations. Appropriate solvent (THF), negative (treatment medium) and positive controls were included and gave expected results. It is concluded that the test substance is negative for the induction of chromosome aberrations under the conditions of this study.
1,2-Bis[dichloro(methyl)silyl]ethane has been tested for mutagenicity in mouse lymphoma L5178Y cells according to OECD 490 and under GLP (Eurofins, 2016). No test-substance induced increase in the number of mutations was observed. Appropriate solvent, negative (treatment medium) and positive controls have been used and gave the expected results. It is concluded that the test substance is negative for mutagenicity to mammalian cells under the conditions of the test.
Justification for classification or non-classification
Based on the available data for 1,2-bis[dichloro(methyl)silyl]ethane, no classification for genetic toxicity is required according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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