Registration Dossier

Diss Factsheets

Administrative data

Description of key information

1,2-bis[dichloro(methyl)silyl]ethane is a chlorosilane, generating hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vivo skin and eye irritation studies (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

1,2-bis[dichloro(methyl)silyl]ethane hydrolyses rapidly in contact with water and moist air, releasing four moles of hydrogen chloride (HCl) for each mole of parent material. Although the irritation/corrosion studies available are limited, their findings support the severe skin, eye and respiratory damage that would be expected due to release of HCl.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

1,2-bis[dichloro(methyl)silyl]ethane is classified 'Skin Corr. 1A' with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008. The additional hazard statement 'EUH071 Corrosive to the respiratory tract' (1272/2008/EC) is applied, in accordance with related chlorosilane substances.