Registration Dossier
Registration Dossier
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EC number: 222-123-0 | CAS number: 3353-69-3
Endpoint summary
Administrative data
Description of key information
1,2-bis[dichloro(methyl)silyl]ethane is a chlorosilane, generating hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vivo skin and eye irritation studies (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
1,2-bis[dichloro(methyl)silyl]ethane hydrolyses rapidly in contact with water and moist air, releasing four moles of hydrogen chloride (HCl) for each mole of parent material. Although the irritation/corrosion studies available are limited, their findings support the severe skin, eye and respiratory damage that would be expected due to release of HCl.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
1,2-bis[dichloro(methyl)silyl]ethane is classified 'Skin Corr. 1A' with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008. The additional hazard statement 'EUH071 Corrosive to the respiratory tract' (1272/2008/EC) is applied, in accordance with related chlorosilane substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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