Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
ToxPlanet Research

Data source

Reference
Reference Type:
secondary source
Title:
ToxPlanet Research
Author:
ERM
Year:
2017

Materials and methods

In vitro test system

Source species:
rabbit

Test animals

Species:
rabbit

Results and discussion

In vivo

Results
Irritation parameter:
other: administration on to skin (rabbit)
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
LDLo: 2 gm/kg (administration onto the skin, rabbit) :
500 mg dose, moderate irr effects (administration onto the skin, rabbit)

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria