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EC number: 430-740-3 | CAS number: -
The ability of treated animals to mate and to produce viable offspring was influenced by the test substance treatment. The dose-response increase in prenatal and postnatal mortality of offspring was recorded.
Decrease of body weight and food consumption of treated males and females was observed. Quality of sperms of parental males were adversely influenced by the test substance treatment.Pathological changes associated with the test substance treatment were found in liver in males and females. Changes in reproductive parameters was observed in all treated animals. Development of pups were negatively influenced by the test substance treatment. Increased mortality of pups and consequently decreased survival index were recorded.
Based on the results of the test performed according to OECD 421, the tested substance showed some effects both on parental animales and litters. The NOAEL (No Observed Adverse Effect Level) for the REPRODUCTION and DEVELOPMENT was established as 125mg/kg body weight/day.
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