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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

The microbial inhibition of Liraglutide precursor is assumed to be comparable to that of the source substance S2 (MI3) because of the high degree of structural similarity:

•       Liraglutide precursor and the source substance belong to the same chemical categories: human insulins, polypeptides and proteins

•       Liraglutide precursor and the source substance are composed of polypeptide containing amino acids

The resulting EC50 values after 30 minutes and 180 minutes in the microbial inhibition study with the source substance S2 (MI3) were > 500 mg/L. Liraglutide precursor is predicted to have a toxicity to microorganisms with EC50 > 500 mg/L based on the results in the study with the source substance S2.

Key value for chemical safety assessment

Additional information