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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Henry F. Smyth Jr. Ph.D. , Charles P. Carpenter Ph.D. , Carrol S. Weil , Urbano C. Pozzani , Jean A. Striegel & Judith S. Nycum
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal, 30:5, 470-476, 1969

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study 2-Chlorobutane in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
2-Chlorobutane
Cas Number:
78-86-4
Molecular formula:
C4H9Cl
IUPAC Name:
2-Chlorobutane
Details on test material:
- Name of test material (as cited in study report): 2-Chlorobutane
- Molecular formula (if other than submission substance): C4H9Cl
- Molecular weight (if other than submission substance): 92.5681 g/mole
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Chlorobutane
- Molecular formula (if other than submission substance): C4H9Cl
- Molecular weight (if other than submission substance): 92.5681 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specifiednot specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
17 460 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality observed in treated rats.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 17460 mg/kg bw (11174—27324) when rat were treated with 2-Chlorobutane orally.
Executive summary:

In a acute oral toxicity study, rat were treated with 2-Chlorobutane in the concentration of 17460 mg/kg bw orally. 50 % mortality observed in17460 mg/kg bw treated rats. Therefore,LD50 was considered to be 17460 mg/kg bw (11174—27324) when rat were treated with 2-Chlorobutane orally.