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Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06-04-2017 – 29-04-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Principles of method if other than guideline:
The water solubility determination of test substance 4-chloro-N-methylpiperidine was done as per the shake flask method
GLP compliance:
no
Type of method:
other: spectrophotometric method
Specific details on test material used for the study:
- Name of test material: 4-chloro-1-methylpiperidine
- Molecular formula: C6H12ClN
- Molecular weight: 133.621 g/mol
- Smiles notation: N1(CCC(CC1)Cl)C
- InChl: 1S/C6H12ClN/c1-8-4-2-6(7)3-5-8/h6H,2-5H2,1H3
- Substance type: Organic
- Physical state: Liquid
Key result
Water solubility:
1 532.92 mg/L
Conc. based on:
test mat.
Temp.:
29 °C
Remarks on result:
other: No other data available
Details on results:
The water solubility determination of test substance 4-chloro-N-methylpiperidine was done as per the shake flask method. The solubility was determined to be 1532.92 mg/L at 29 0C.

 Sample stirring  

Concentration obtained on

the basis of standard curve

  Dilution factor  

Solubility value obtained

(mg/L)
24 hr  --  --   --
 48 hr  306.8948 5   1534.474 mg/L
 72 hr  306.2746 5   1531.373 mg/L

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

=(1534.474+1531.373)/2

=1532.92 mg/L

Conclusions:
The water solubility determination of test item 4-chloro-N-methylpiperidine;CAS No.5570-77-4 was done by spectrophotometric method. The water solubility was determined to be 1532.92 mg/L at 29°C. This value indicates that 4-chloro-N-methylpiperidine is moderately soluble in water
Executive summary:

The water solubility determination of test item 4 -chloro-N-methylpiperidine (CAS No. 5570 -77 -4) was done as per the OECD guideline 105 byspectrophotometric analytical method as per OECD 101. The solubility of 4 -chloro-N-methylpiperidine (CAS:5570 -77-4 ) in water was determined to be 1532.92 mg/L at 29°C.

This value indicates that 4-chloro-N-methylpiperidine is moderately soluble in water

Description of key information

The water solubilitydetermination of test item 4-chloro-N-methylpiperidine;CAS No.5570-77-4 was doneby spectrophotometric method. The water solubility was observed to be 1532.92 mg/L at 29°C. This value indicates that 4-chloro-N-methylpiperidine is moderately soluble in water

Key value for chemical safety assessment

Water solubility:
1 532.92 mg/L
at the temperature of:
29 °C

Additional information

The water solubility determination of test item 4 -chloro-N-methylpiperidine (CAS No. 5570 -77 -4) was done as per the OECD guideline 105 byspectrophotometric analytical method as per OECD 101. The solubility of (4 -chloro-N-methylpiperidine of 5570 -77 -4 ) in water was determined to be 1532.92 mg/L at 29°C.

This value indicates that 4-chloro-N-methylpiperidine is moderately soluble in water