Registration Dossier
Registration Dossier
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EC number: 943-653-5 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test material
- Reference substance name:
- Ionone, methyl-
- EC Number:
- 215-635-0
- EC Name:
- Ionone, methyl-
- Cas Number:
- 1335-46-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- Ionone, methyl
- Details on test material:
- Test material was a mixture of 14C labeled and non-radioactive material dissolved in ethanol at a concentration of 10%.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14
Test animals
- Species:
- pig
Administration / exposure
- Vehicle:
- ethanol
- Duration of exposure:
- 6 hours
- Doses:
- 10% in ethanol
Results and discussion
Any other information on results incl. tables
600 µg/cm2: skin absorption
After 6 hours contact with pig skin approximately 2/3 of the test material applied was recovered with 358.72 ug/cm2 found on the skin surface, 24.92 ug/cm2 found in the horny layer of the skin, 16.32 ug/cm2 found in the remaining skin tissue layers, and 0.16 ug/cm2 found in the chamber liquid.
The unrecovered test material was presumably lost by evaporation from the skin surface.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
