3-aminopropylmethylamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from NTRL

Data source

Reference

Reference Type:

secondary source

Title:

Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.

Author:

NTRL

Year:

1992

Bibliographic source:

OTS0555335, NTRL, dated 9/4/92

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute inhalation toxicity study of 3-Methylaminopropylamine in rats

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-aminopropylmethylamine

EC Number:

228-544-6

EC Name:

3-aminopropylmethylamine

Cas Number:

6291-84-5

Molecular formula:

C4H12N2

IUPAC Name:

(3-aminopropyl)(methyl)amine

Details on test material:

SMILES:CNCCCN

Specific details on test material used for the study:

- Name of test material (as cited in study report): 3-Methylaminopropylamine
- Molecular formula (if other than submission substance): C4H12N2
- Molecular weight (if other than submission substance): 88.1528 g/mole
- Substance type: Organic

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Mass median aerodynamic diameter (MMAD):

7.2 µm

Geometric standard deviation (GSD):

1.41

Remark on MMAD/GSD:

not specified

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel and glass inhalation chambers
- Exposure chamber volume: 420 liters.
- Method of holding animals in test chamber: whole body
- Source and rate of air: Atmospheres were produced by passing air over the surface of the liquid contained in a three necked flask maintained at 35° C tor 61 mg/m and 50° C for 189.3, mg/m3 .
- Method of conditioning air:
- System of generating particulates/aerosols: Vapor laden air exiting the flask vas diluted at a T at which point a chemical or physical reaction occurred resulting in the production of an aerosol.
- Method of particle size determination: Royco Analyzer over the course or exposure resulted in a stable distribution with an aerodynamic mass median diameter of 7.2µm and geometric standard deviation of 1.41.
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:

TEST ATMOSPHERE
- Brief description of analytical method used: Approximately 82% of the particles was less than 10 um in diameter. Chamber concentrations were determined every 0.5 hour by gas chromatography of sample collected in midget impingers.
- Samples taken from breathing zone: yes

VEHICLE
- Composition of vehicle (if applicable):
- Concentration of test material in vehicle (if applicable):
- Justification of choice of vehicle:
- Lot/batch no. (if required):
- Purity:

TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):

CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration:

Analytical verification of test atmosphere concentrations:

yes

Remarks:

by gas chromatography

Duration of exposure:

6 h

Remarks on duration:

not specified

Concentrations:

0.0, 0.61 and 189.3 mg/m3

No. of animals per sex per dose:

Total: 12
0.0 mg/m3 : 4
0.61 mg/m3 : 4
189.3 mg/m3 : 4

Control animals:

yes

Details on study design:

- Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: Mortality was observed.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 189.3 mg/m³ air

Based on:

test mat.

Exp. duration:

6 h

Remarks on result:

other: No mortality observed

Mortality:

No mortality observed at 189.3 mg/m3

Clinical signs:

other: not specified

Body weight:

not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LC50 was considered to be > 189.3 mg/m3 when rat was exposed with 3-aminopropylmethylamine by Whole body inhalation for 6 hours.

Executive summary:

The acute inhalation toxicity study, rat were exposed with 3-aminopropylmethylamine in the concentration of 0.0, 0.61 and 189.3 mg/m³by Whole body inhalation for 6 hours.No mortality observed at189.3 mg/m³. Therefore, LC50 was considered to be > 189.3 mg/m³when rat was exposed with3-aminopropylmethylamineby Whole body inhalation for 6 hours.