Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-133-1 | CAS number: 1304-56-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study contains no information on substance or animals. Exposure period is not properly defined with BeO. No raw data presented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 953
Materials and methods
- Principles of method if other than guideline:
- Inhalation of BeO in dogs and effect on blood concentration on lipids and cholesterol
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- BeO, no other information
Constituent 1
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No information
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Remarks:
- most likely whole body
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: No information
- Details on inhalation exposure:
- Dogs were exposed for six hours a day, 5 days per week, to 3.6 mg/m3 BeO
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Not clear
- Frequency of treatment:
- 6 hours a day, 5 days per week
- No. of animals per sex per dose:
- 4 dogs
- Details on study design:
- Limited information on study design. BeO is included as part of a larger study including BeSO4 and BeF.
The levels of phospholipids and free cholesterol was measured in exposed animals.
Examinations
- Observations and examinations performed and frequency:
- No information
- Sacrifice and pathology:
- No information
- Statistics:
- No information
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- BeO caused a 1 value above 2 standard deviations in the phospholipid/free cholesterol ratio.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks:
- Study not sufficient to determine NOAEL
- Effect level:
- ca. 3.6 mg/m³ air
- Sex:
- not specified
- Basis for effect level:
- other: Beryllium oxide at this concentration produced a slight increase in phospholipid: free cholesterol ratio. The strenght of this finding and the relevance (biological implications) is highly uncertain.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Not enough information to conclude on results or validity of study.
- Executive summary:
Dogs were exposed to BeO over a not properly defined period. This exposure caused an increase in the ratio of phospholipids to free cholesterol. The relevance of this finding is highly uncertain.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
