Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

OECD and GLP compliant study on oral acute toxicity is available. LD50 > 2000 mg/kg bw.
The other available studies were performed via inhalation or intratracheal intubation.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

BeO is of low acute toxicity through all available routes of applications as evidenced by the lack of reported deaths and other clinical signs of toxicity. The most common observation is the formation of granulomas in animals exposed to BeO and significant persistence of BeO in lung. This observation is regardless of exposure route and species studied. Another common observation is the effect of calcination temperature of BeO. Lower calcination temperature is generally associated with faster clearance and more severe signs of toxicity.

Justification for classification or non-classification

Beryllium oxide ( EC No 215 -133 -1, CAS No 1304 -56 -9) is listed in table 3.1 List of harmonised classification and labelling of hazardous substances of REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (CLP).

According to table 3.1 the substance is classified as Acute Tox. 3 (H 301). However, results of Mallaun (2010; key study on acute oral toxicity) show a LD50 > 2000 mg/kg bw. and the substance beryllium oxide has not to be classified as acute oral toxic.