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EC number: 286-249-8 | CAS number: 85203-56-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Eucalyptus maculata citriodora, Myrtaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Maximization test (modified after JID 47:393-409):
- Principle of test: To determine the skin sensitizing and skin irriating potential of eucalyptys citriodora
- Short description of test conditions: Forty five healthy inmate volunteers were screened and 32 completed the study.
- Parameters analysed / observed: Skin sensitization and skin irritation. - GLP compliance:
- no
Test material
- Reference substance name:
- Eucalyptus citrodora
- IUPAC Name:
- Eucalyptus citrodora
- Details on test material:
- - Name of test material (as cited in study report): Eucalyptus citriodora
- Physical state: Liquid
- Analytical purity: Confidential information
- Lot/batch No.: Confidential information
- Expiration date of the lot/batch: Confidential information
- Storage condition of test material: Room temperature in the dark
Constituent 1
Test animals
- Species:
- other: human
- Strain:
- other: not applicable
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Pretreatment with Sodium Lauryl sulfate (SLS)
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- Not specified
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- 72 hours
- Number of animals:
- 32 humans
- Details on study design:
- TEST SITE
- Area of exposure: Volar aspects of the forearm
- Type of wrap if used: Occlusion
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
OBSERVATION TIME POINTS
- 48h and 72h after exposure
SCORING SYSTEM:
-Assumed according to 'Magnusson and Kligman grading scale for the evaluation of challenge patch test reactions' or similar scoring system.
OTHER
-Materials were pretested to determine whether Sodium Lauryl Sulfate (SLS) pretreatment was required; all subjects were pretreated with 5% SLS (patch sites were pretreated for 24 hours). The materials were applied under occlusion on the volar aspects of the forearm for 5 alternate day 48 hour periods. After a 10 -14 day resting period, challenge patches were applied under occlusion to fresh sites for 48 hours. (Challenge application were preceded by 30 -minute applications of 5% SDS, and without SLS on the right side.)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: human
- Time point:
- other: observation period after challenge
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No reactions were considered significantly irritant or allergic in the subjects tested.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP criteria
- Conclusions:
- Under the conditions of this study, the testing material gave no reactions that were considered significantly irritant or allergic. Based on this result, the test substance does not need to be classified for skin irritation in accordance with the criteria outlined in the CLP Regulation (1272/2008/EC).
- Executive summary:
The sensitizing and irritation potential of Eucalyptus Citrodora on humans was tested in a maximization procedure. Materials were pretested to determine whether Sodium Lauryl Sulfate (SLS) pretreatment was required; all subjects were pretreated with 5% SLS (patch sites were pretreated for 24 hours). The materials were applied under occlusion on the volar aspects of the forearm for 5 alternate day 48 hour periods. After a 10 -14 day resting period, challenge patches were applied under occlusion to fresh sites for 48 hours. (Challenge application were preceded by 30 -minute applications of 5% SDS, and without SLS on the right side.) Under the conditions of this study, the testing material gave no reactions that were considered significantly irritant or allergic. Based on this result, the test substance does not need to be classified for skin irritation in accordance with the criteria outlined in the CLP Regulation (1272/2008/EC).
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