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Administrative data

First-aid measures

Ingestion: Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the
exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed
subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation: Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing
is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed subject
should be kept warm and at rest. Obtain medical attention in cases of known or possible over exposure, or
with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects,
which may be delayed.

Skin contact: Using appropriate personal protective equipment, remove contaminated clothing and flush
exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be
immediate or delayed.

Eye contact: Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain
medical attention.

NOTES TO HEALTH PROFESSIONALS
Medical Treatment: Because of the potential for acute or delayed eye damage, consider referral to an ophthalmologist.In allergic individuals,
exposure to this material may require treatment for initial or delayed allergicsymptoms and signs. This may include immediate and/or
delayed treatment of anaphylactic reactions.Treat according to locally accepted protocols. For additional guidance, refer to the local
poison control information Centre.

Medical Conditions Caused or Aggravated by Exposure: Ocular symptoms may be indicative of allergic reaction.This material
may cause or aggravate effects on nervous system.This material is clinically incompatible with monoamine oxidase inhibitors.

Health Surveillance Procedures: The need for pre-placement and periodic health surveillance must be determined by risk
assessment. Following assessment, if the risk of exposure is considered significant then exposed individuals should
receive health surveillance focused on detecting skin conditions.In the event of overexposure, individuals should receive
post exposure health surveillance focused on detecting skin conditions and other allergy symptoms.





Fire-fighting measures

Fire and Explosion Hazards: This material is non-combustible.Dust clouds are potentially highly sensitive to ignition from incentive electrostatic discharges. Dust clouds are of low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer observed up to 400°C.
Ignition of a dust cloud produces a very strong dust explosion. Moderate pressure between 6 and 8 bar is produced during a dust explosion.

Suitable Extinguishing Media :No special requirements needed. Water is recommended for fires involving packaging.

Special Protective Equipment and Precautions for Firefighters: Since toxic, corrosive or flammable vapours might be evolved from fires
involving this material, self-contained breathing apparatus and full protective equipment are recommended for firefighters. Move
containers from the fire area if possible without increased personal risk. If possible, contain and collect firefighting water for later disposal.

Specific Hazards arising from the Material: Toxic, corrosive or flammable thermal decomposition products, which might include
fluorine compounds, are expected when the material is exposed to fire.

Accidental release measures

Personal Precautions: Fence or cordon the affected area and do not allow individuals to touch or walk through
the spilled material unless wearing appropriate protective clothing. Avoid dust generation.

Environmental Precautions: Prevent entry into waterways, sewers, surface drainage systems and poorly
ventilated areas. If spill is outdoors, cover with plastic sheet to minimize spreading or contact with rain.

Clean-up Methods: Collect and place it in a suitable, properly labelled container for recovery or disposal.
Following removal of spillage, wash down spillage area with copious amounts of water only if waste water can be directed
to an on-site waste water treatment system.

Decontamination Procedures: No specific decontamination or detoxification procedures have been identified for this material.
Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of this SDS), for clean-up and
decontamination operations.

Handling and storage

PRECAUTIONS FOR SAFE HANDLING
GSK Process Hazard Category: 3
General Requirements: Avoid dispersion as a dust cloud.Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended toprovide routine control of fire and explosion hazards during handling of this material.

Ignition Controls: Bond and earth (ground) all plant and equipment to ensure that no isolated conductors
are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges
of many hundreds of milli-Joules.Consider earthing (grounding) personnel dealing with dusty operations.
An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but
have been recorded up to 100 mJ.Minimise the use of plastics when handling this material. The maximum
surface temperature of enclosures potentially exposed to this material should be the lower of the values
obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less than the
minimum ignition temperature of the dust layer, with a maximum temperature of 325 °C.

Protective Systems: Assess operations based upon available dust explosion information to determine
the suitability of preventive or protective systems as precautionary measures against possible dust
explosions. If prevention is not possible, consider protection by use of containment, venting or
suppression of dust handling equipment. Where explosion venting is considered the most appropriate
method of protection, vent areas should preferably be calculated based on the Kst rather than the St
value. If nitrogen purging is considered as the protective system, it must operate with an oxygen level
below the limiting oxygen concentration. The system should include an oxygen monitoring and shut-
down facility in the event of excessive oxygen being detected. At both ambient and low humidity, this
material is of low conductivity. Generation of electrostatic charge is considered likely to occur even when
handled in an earthed (grounded) environment. At ambient humidity, this material has a very long
charge relaxation time. Accumulation of electrostatic charge is considered very likely to occur even when
handled in an earthed(grounded) environment. Under these conditions, it is considered that this
material might present a very high risk of producing an electrostatic discharge. At low humidity, this
material has a long charge relaxation time. Accumulation of electrostatic charge is considered likely to
occur even when handled in an earthed (grounded) environment. Under these conditions, it is
considered that this material might present a very high risk of producing an electrostatic discharge.

CONDITIONS FOR SAFE STORAGE
Keep in tightly closed containers or packages away from moisture and away from sources of ignition.
Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately
20 degrees C).

Transport information

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

OCCUPATIONAL EXPOSURE LIMITS
GSK Occupational Hazard Category: 2
GSK Occupational Exposure Limit: 100 MCG/M3 (8 HR TWA)
ENGINEERING CONTROLS
Exposure Controls: An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.

Containment: Open handling should be limited to small quantities. Consider use of enclosures.

Ventilation: Local exhaust ventilation (LEV) should be applied at the source to capture contaminants
from open or semi-enclosed operations.

Administrative: Entry to the working area should be controlled.

PERSONAL PROTECTIVE EQUIPMENT
Eye Protection: Wear approved cover goggles if eye contact is possible. In addition, a face
shield is recommended.

Gloves:The selection of gloves for a specific activity must be based on the material's properties and on
Possible permeation and degradation that may occur under the circumstances of use. Glove selection
must take into account any solvents and other hazards present. Potential allergic reactions can occur
with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised
if insufficient data are available and further guidance should be sought from your local EHS department.

Respirators: If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and warning
properties of substances present. RPE should provide full face protection. Follow local regulations for
respirator use in the workplace.

Other Equipment or Procedures: An eye wash station should be available. Wear appropriate clothing to avoid skin contact.

Stability and reactivity

Conditions to Avoid: Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud

Disposal considerations

Disposal Recommendations: Collect for recycling or recovery if possible. The recommended method of disposal is incineration.Wherever possible, disposal should be in an on-site licensed chemical incinerator, if allowed by the incinerator license or permit. If no on-site incinerator is available, dispose of material in a licensed commercial chemical incinerator.

Regulatory Requirements: Observe all local and national regulations when disposing of this material.

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