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Vapour pressure

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vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 November 2004 to 7 December 2004
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: vapour pressure balance
Key result
25 °C
Vapour pressure:
> 0 Pa

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 ºC.

Run 5 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 109 ºC (382.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of -1500 K is imposed upon it.

The value of -1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25 ºC gave a vapour pressure of 2.513 x 10^-4 Pa which has been taken as a maximum for this material.

The test substance did not change in appearance under the conditions used in the determination.

Under the conditions of the test, the vapour pressure of the test substance was determined to be 2.6 x 10E-4 Pa.
Executive summary:

In a GLP compliant vapour pressure study conducted in line with EU Method A.4, the vapour pressure of butanoic acid, 4-[[4-[7-chloro-6-(1,1-dimethylethyl)-3H-pyrazolo[1,5,b][1,2,4]triazol-2-yl]phenyl]amino-4-oxo-, tetradecyl ester was determined using the balance method. The vapour pressure of the substance was determined to be 2.6 x 10^-4 Pa at 25 ºC.

Description of key information

Key study:- Tremain (2004) 'Determination of hazardous physico-chemical properties' conducted in line with EU Method A.4. The vapour pressure of the test substance was determined to be 2.6 x 10^-4 Pa at 25 ºC.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The key study (Tremain, 2004) was performed in compliance with GLP and to the EU Method A.4 with a sufficient level of detail to assess the quality of the presented data. The study was performed to a good standard and in line with an accepted, standardised guideline and was assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch et al. (1997). The vapour pressure of the test substance was determined to be 2.6 x 10^-4 Pa at 25 ºC.