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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 - 26 October 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.1
Temp.:
20 °C
pH:
7.42

Results

The log Pow-value of the test item was found to be 4.10. The data are given in the following table.

 

 

Results of Log Pow-Values of the test item

Test Item

Retention

Time [min]

Log k'

Log Pow

Mean

Overall Mean

Solution 1

1st run

8.287

0.6602

4.108

4.10

4.10 ± 0.01

2nd run

8.293

0.6560

4.095

Solution 2

1st run

8.287

0.6556

4.094

4.09

2nd run

8.293

0.6536

4.087

Conclusions:
A log Kow of 4.10 at 20 °C and pH 7.42 was determined for the test substance according to OECD 117.

Description of key information

Log Kow: 4.10 at 20 °C and pH 7.42 (OECD 117, HPLC method)

Key value for chemical safety assessment

Log Kow (Log Pow):
4.1
at the temperature of:
20 °C

Additional information