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EC number: 238-098-4
CAS number: 14228-73-0
A cyclohexane dimethylol diglycidyl
ether-containing mixture was evaluated for genetic activity in the AMES preincubation/plate
incorporation bacterial mutagenicity assay, with and without the
addition of a mammalian metabolic activation preparation. The study was
conducted using Salmonella typhimurium bacterial tester strains TA98,
TA100, TA1535, TA1537 and TA1538. The test material was tested in all
strains at 10, 1.0, 0.1, 0.01 and 0.001 (except TA100) mg per plate.
Toxicity was observed at 10 mg/plate in all strains without metabolic
activation. The test material was found to produce a dose-related
mutagenic response in strains TA100 and TA1535, strains which are
sensitive to base-pair substitution mutagens. The observed mutagenic
response in strains TA100 and TA1535 was markedly enhanced by the
presence of the mammalian metabolic activation preparations. Thus, cyclohexane
dimethylol diglycidyl ether is considered to be a bacterial mutagen of
the base-pair substitution type when evaluated in this highly sensitive
bacterial mutagenicity assay.
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