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Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Test method was equivalent to OECD guideline 203. No GLP.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
yes
Remarks:
(There is no evidence that the concentration of the substance being tested has been satisfactorily maintained throughout the test)
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
no
Test organisms (species):
Gambusia affinis
Details on test organisms:
TEST ORGANISM
- Common name: Mosquito fish
- Source: The fishes were all collected from Stillwater Creek in Payne County, Okla., where they encountered turbidity in their normal habitat.
- Age at study initiation (mean and range, SD): Practically all the fishes used were adult females.
- Feeding during test: No

ACCLIMATION
- Acclimation period: The fishes were kept in the laboratory for a period of two to three weeks.
- Type and amount of food: Plankton and detritus, collected locally, were given to the fishes along with various artificial foods.
- Feeding frequency: They were fed as necessary to maintain a healthy condition.
- Health during acclimation period: Many cases of a tail-rot disease were observed in the holding tanks. The tail would begin turning white just in front of the fin, the white area progressing rapidly forward until the fish died. The causative agent was not discovered. Many specimens were lost to this disease until it was discovered that a small amount of terramycin sprinkled on the surface of the water would almost completely eliminate further losses from the disease.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
16-25°C
pH:
6.9 – 8.7
Nominal and measured concentrations:
Nominal concentrations:
The concentrations used for the first experiment were 10, 18, 32, 56 and 100 ppm. When deaths did not occur at these concentrations within 96 hours the same series was run between 100 and 1000 ppm (100, 180, 320, 560, and 1000 mg/L).
Details on test conditions:
TEST SYSTEM
- The experimental aquaria were cylindrical pyrex jars 12 in. high and 12 in. in diameter. Each jar contained 15 L of water at the beginning of the test and water was not replaced.
- Artificial aeration from a compressor served to maintain the oxygen level, to mix the chemical into the water, and to disperse the turbidity-producing soil as long as possible in the mixture.
- No. of organisms per vessel: Ten fishes were used in each aquarium during all experiments and a control aquarium was always maintained with 10 fishes.

TEST MEDIUM / WATER PARAMETERS
- The water used for experimental dilutions and in the control aquaria was brought into the laboratory from two farm ponds. These ponds had a long history of high turbidity.
- The turbid water was carried from the ponds (approximately two miles) in 10-gal. milk cans and immediately emptied into the test aquaria, where it
was allowed to cool or warm to room temperature.
- Intervals of water quality measurement: The temperature, turbidity, and pH of the experimental water were measured after the test substance was added and daily throughout the experiment.

EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Mortality. Survivor observations were made at 24, 48, 72 and 96 hours.
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
251 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
Fish transferred to concentrations between 100 and 1000 ppm swam frantically and at 100 and 180 ppm returned to normal in 24 hours. At 320 ppm and higher all fish were dead at 24 hours.
Sublethal observations / clinical signs:

The (96 h) LC50 for Gambusia affinis is 251 mg/L (basis for effect: mortality).

Validity criteria fulfilled:
not specified
Remarks:
(No data on control results, nor on dissolved oxygen concentrations and there is no evidence that the concentration of the substance being tested has been satisfactorily maintained throughout the test)
Conclusions:
The (96 h) LC50 for Gambusia affinis is 251 mg/L (basis for effect: mortality).
Executive summary:

Ten fish were exposed to test concentrations for a period of 96 hours. The concentrations used for the first experiment were 10, 18, 32, 56 and 100 ppm. When deaths did not occur at these concentrations within 96 hours the same series was run between 100 and 1,000 ppm. The temperature, turbidity, and pH of the experimental water were measured after the test substance was added and daily throughout the experiment. Survivor observations were made at 24, 48, 72 and 96 hours. Test water was maintained at pH 6.9 – 8.7 and 16-25°C.

The (96 h) LC50 for Gambusia affinis is 251 mg/L (basis for effect: mortality).

Fish transferred to concentrations between 100 and 1000 ppm swam frantically and at 100 and 180 ppm returned to normal in 24 hours. At 320 ppm and higher all fish were dead at 24 hours.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Remarks:
Test method according to German Standards Institution, Berlin (Assaying effects of water ingredients on fishes DEV L15). No GLP.
Principles of method if other than guideline:
Method: other: DEV L15: Fischtest (Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische). Rreprint (1976) in: Vom Wasser 46, 291-295. Method of the German Standards Institution, Berlin, Germany (Assaying effects of water ingredients on fishes DEV L15)
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
no
Test organisms (species):
Leuciscus idus melanotus
Details on test organisms:
TEST ORGANISM
- Common name: golden orfe
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Nominal and measured concentrations:
No data
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
410 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
368 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
452 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
Experiments were carried out in two different laboratories, and results were the same.
Sublethal observations / clinical signs:

The LC50 of acetic acid was 410 mg/L (basis for effect: mortality).

Validity criteria fulfilled:
not specified
Remarks:
(There is no data on control groups, no data on analytical monitoring of test substance concentration throughout the test and no data on dissolved oxygen concentration. There is no evidence that constant conditions had been maintained throughout the test)
Conclusions:
The 48h LC50 of acetic acid was 410 mg/L (basis for effect: mortality).
Executive summary:

An acute toxicity test has been performed on Leuciscus idus melanotus according to the German Standard Method for Waste Water and Sludge of 1976.

It was found for the 48 h toxicity on the golden orfe (Leuciscus idus melanotus). The LC50 of acetic acid was 410 mg/L (basis for effect: mortality). Experiments were carried out in two different laboratories, and results were the same.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
The method used was similar to OECD 203 guideline. No GLP. Study realized by US EPA.
Principles of method if other than guideline:
Fathead minnows were exposed under static conditions to a series of concentrations of acetic acid.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Pimephales promelas
Details on test organisms:
TEST ORGANISM
- Common name: Fathead minnow
- Source: Environmental Research Laboratory Duluth.
- Age at study initiation (mean and range, SD): 4 to 8 weeks old
- Length at study initiation (length definition, mean, range and SD): 1.1 to 3.1 cm.

ACCLIMATION
Fish were acclimated in flowing water 11 cm deep in a holding trough (360 cm long by 58 cm wide by 31 cm deep) for at least 48 hr before the tests.
- Type and amount of food: Glencoe trout chow no. 3 granules.
Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h
Test temperature:
18-22 ºC
Nominal and measured concentrations:
No data
Details on test conditions:
TEST SYSTEM
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: 3-L cylindrical glass battery jars containing 2 L of test water.
- Aeration: No
- No. of organisms per vessel: 10 fish
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1 or 2

EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Lethality.
Complete immobilization of the fish was considered as the biological endpoint and equated with death. Fish mortality was measured after 1, 24, 48, and 96 hr.
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
>= 79 - <= 88 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Sublethal observations / clinical signs:

The 96 h-LC50 was 79-88 mg/L (basis for effect: mortality).

Validity criteria fulfilled:
yes
Conclusions:
The 96 h-LC50 was 79-88 mg/L (basis for effect: mortality).
Executive summary:

Fathead minnows were exposed under static conditions to a series of concentrations of ammonium acetate.

The 96 h-LC50 was 79-88 mg/L (basis for effect: mortality).

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
A scientific approach. No GLP
Principles of method if other than guideline:
The EC50 (median concentration inducing malformation in 50% of surviving embryos) and the LC50 at 120 hr were determined using Litchfield-Wilcoxon probit analysis.
GLP compliance:
no
Analytical monitoring:
no
Test organisms (species):
Pimephales promelas
Details on test organisms:
TEST ORGANISM
- Age at study initiation (mean and range, SD): embryos of 6 days
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
120 h
Hardness:
Reconstituted water medium contained 400 mg NaCl, 96 mg NaHCO3, 30 mg KCl, 14 mg CaC12, 60 mg CaSO4 2H20, and 75 mg MgSO4 per L of deionized distilled water.
Test temperature:
24± 2 °C
Reference substance (positive control):
no
Duration:
120 h
Dose descriptor:
LC50
Effect conc.:
13 330 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: 12.43-14.31
Validity criteria fulfilled:
yes
Conclusions:
LC50 for Pimephales embryos (120h) was 13.33g/L.
Executive summary:

In the study LC50 for Pimephales embryos was determined, in 120h was 13.33g/L.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
A scientific, very well documented approach. No GLP
Principles of method if other than guideline:
Fathead minnows (Pimephales promelas), were used in this study. The temperature, dissolved oxygen (DO) (Weston and Stock DO analyzer), and pH of the solutions were measured prior to beginning each study and at 24-hr intervals thereafter. The desired pH of the solutions at the beginning of exposure was 6.5-8.5. The fish in each aquarium were observed closely for the first 4-8 hr and at 24, 48, 72, and 96 hr. 20 fathead minnows were placed in each aquarium. The time required to kill 50% of the fish (LTE„) was approximated by visually fitting a straight line, on log-probability paper, to the observed data. Aquaria with no contaminant added were run with each set of tests as experimental controls but only rarely did a control fish die.
GLP compliance:
no
Analytical monitoring:
no
Test organisms (species):
Pimephales promelas
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
10 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
yes
Conclusions:
LC50 for Fathead minnow (96h) was 10g/L.
Executive summary:

In the study was determined that at 96h LC50 was 10g/L for Fathead minnow.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Triacetoxyvinylsilane undergoes rapid hydrolysis in aqueous to acetic acid and the corresponding trisilanols. Trisilanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to the acetic acid and their values are comparable.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
323.62 mg/L
Remarks on result:
other: (Read-across approach from acetic acid effect concentration based on the estimated concentration of the test material and basis for effect: mortality)
Details on results:
Based on the experimental results obtained with the supporting substance acetic acid (96h LC50 =251 mg/L for Gambusia affinis), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 323.62 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the experimental results obtained with the supporting substance acetic acid (96h LC50 =251 mg/L for Gambusia affinis), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 323.62 mg/L.
Executive summary:

Based on the experimental results obtained with the supporting substance acetic acid (96h LC50 =251 mg/L for Gambusia affinis), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 323.62 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Triacetoxyvinylsilane undergoes rapid hydrolysis in aqueous to acetic acid and the corresponding trisilanols. Trisilanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to the acetic acid and their values are comparable.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
528.62 mg/L
Remarks on result:
other: (Read-across approach from acetic acid effect concentration based on test material and basis for effect: mortality)
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
474.47 mg/L
Remarks on result:
other: (Read-across approach from acetic acid effect concentration based on test material and basis for effect: mortality)
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
582.77 mg/L
Remarks on result:
other: (Read-across approach from acetic acid effect concentration based on test material and basis for effect: mortality)
Details on results:
Based on the experimental results obtained with the supporting substance acetic acid (48h LC50 = 410 mg/L for Leuciscus idus melanotus), the read-across approach is applied and the 48h LC50 for triacetoxyvinylsilane is calculated to be 528.62 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the experimental results obtained with the supporting substance acetic acid (48h LC50 = 410 mg/L for Leuciscus idus melanotus), the read-across approach is applied and the 48h LC50 for triacetoxyvinylsilane is calculated to be 528.62 mg/L.
Executive summary:

Based on the experimental results obtained with the supporting substance acetic acid (48h LC50 = 410 mg/L for Leuciscus idus melanotus), the read-across approach is applied and the 48h LC50 for triacetoxyvinylsilane is calculated to be 528.62 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Triacetoxyvinylsilane undergoes rapid hydrolysis in aqueous to acetic acid and the corresponding trisilanols. Trisilanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to the acetic acid and their values are comparable.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
>= 101.86 - <= 113.46 mg/L
Remarks on result:
other: (Read-across approach from acetic acid effect concentration based on the nominal concentration of the test material and basis for effect: mortality)
Details on results:
Based on the experimental results obtained with the supporting substance acetic acid (96h LC50 = 79-88 mg/L for Fathead minnow), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 101.86-113.46 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the experimental results obtained with the supporting substance acetic acid (96h LC50 = 79-88 mg/L for Fathead minnow), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 101.86-113.46 mg/L.
Executive summary:

Based on the experimental results obtained with the supporting substance acetic acid (96h LC50 = 79-88 mg/L for Fathead minnow), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 101.86-113.46 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Triacetoxyvinylsilane undergoes rapid hydrolysis in aqueous to acetic acid and the corresponding trisilanols. Trisilanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to the acetic acid and their values are comparable. Acetic acid and its salts are grouped together because of their close structural relationship (US EPA officially recognises acetic acid and acetates as a subcategory). Therefore, sodium acetate has comparable values with acetic acid and the target substance triacetoxyvinylsilane.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Duration:
120 h
Dose descriptor:
LC50
Effect conc.:
12 580 mg/L
Remarks on result:
other: (Read-across approach from sodium acetate effect concentration based on the nominal concentration of the test material and basis for effect: mortality)
Details on results:
Based on the experimental results obtained with the supporting substance sodium acetate (120h LC50 = 13330 mg/L for Pimephales promelas), the read-across approach is applied and the 120h LC50 for triacetoxyvinylsilane is calculated to be 12580 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the experimental results obtained with the supporting substance sodium acetate (120h LC50 = 13330 mg/L for Pimephales promelas), the read-across approach is applied and the 120h LC50 for triacetoxyvinylsilane is calculated to be 12580 mg/L.
Executive summary:

Based on the experimental results obtained with the supporting substance sodium acetate (120h LC50 = 13330 mg/L for Pimephales promelas), the read-across approach is applied and the 120h LC50 for triacetoxyvinylsilane is calculated to be 12580 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Triacetoxyvinylsilane undergoes rapid hydrolysis in aqueous to acetic acid and the corresponding trisilanols. Trisilanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to the acetic acid and their values are comparable. Acetic acid and its salts are grouped together because of their close structural relationship (US EPA officially recognises acetic acid and acetates as a subcategory). Therefore, sodium acetate has comparable values with acetic acid and the target substance triacetoxyvinylsilane.
See attached the reporting format.
Reason / purpose for cross-reference:
read-across source
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
9 440 mg/L
Basis for effect:
mortality (fish)
Remarks on result:
other: (Read-across approach from sodium acetate effect concentration based on the nominal concentration of the test material and basis for effect: mortality)
Details on results:
Based on the experimental results obtained with the supporting substance sodium acetate (96h LC50 = 10000 mg/L for Pimephales promelas), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 9440 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the experimental results obtained with the supporting substance sodium acetate (96h LC50 = 10000 mg/L for Pimephales promelas), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 9440 mg/L.
Executive summary:

Based on the experimental results obtained with the supporting substance sodium acetate (96h LC50 = 10000 mg/L for Pimephales promelas), the read-across approach is applied and the 96h LC50 for triacetoxyvinylsilane is calculated to be 9440 mg/L.

Description of key information

Weight of evidence: Based on experimental results obtained in short-term toxicity to fish studies (reliability 2) with supporting substance acetic acid, read-across approach was applied and LC50 (96h) for triacetoxyvinylsilane was calculated to be 101.86 mg/L (based on mortality).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
101.86 mg/L

Additional information

Weight of evidence:

Read-across from experimental results with acetic acid:

In the first study, Wallen et. al., 1957 (reliability 2), an acute toxicity testwas performed according to OECD Guideline 302. The LC50 (based on mortality) of test material, acetic acid, in Gambusia affinis for 96h exposure period was 251 mg/L. Based on this experimental result, read-across approach was applied and LC50 (96h, based on mortality) for triacetoxyvinylsilane was calculated to be 323.62 mg/L.

In the study of Juhnke et. al, 1978 (reliability 2), an acute toxicity test was performed according to German Standard Method for Waste Water and Sludge of 1976 with test material acetic acid. The LC50 for 48h toxicity on the golden orfe (Leuscicus idul melanotus) was 410 mg/L (basis for effect: mortality). Based on this result, read-across approach was applied and LC50 (48h, based on mortality) for triacetoxyvinylsilane was calculated to be 528.62 mg/L.

In the study of Mattson et. al., 1976 (reliability 2), Fathead minnow (Pimephales promelas) were exposed under static conditions to a series of concentrations of acetic acid. The 96 h LC50 was 79-88 mg/L (basis for effect: mortality). Based on this experimental result obtained with the supporting substance acetic acid, read-across approach was applied and the LC50 (96h) for triacetoxyvinylsilane was calculated to be 101.86 -113.46 mg/L (bassis for effect: mortality).

Supporting studies:

Read-across from experimental results with sodium acetate:

There are two supporting studies from DeYoung et. al., 1996 and Terhaar et. al., 1972, both with reliability 2 performed for the supporting substance sodium acetate. In the first one and based on the experimental results (120h LC50 = 13330 mg/L for Pimephales promelas), read-across approach was applied and the 120h LC50 for triacetoxyvinylsilane was calculated to be 12580 mg/L. In the second study and based on the experimental results (96h LC50 = 10000 mg/L for Pimephales promelas), the read-across approach was applied and the 96h LC50 for triacetoxyvinylsilane was calculated to be 9440 mg/L.

According to the available information on short-term toxicity to fish, could be pointed out that the toxicity of triacetoxyvinylsilane is caused by the pH effect of acetic acid since the read-across approach applied from experimental data with acetic acid (LC50 (96): 323.62 mg/L; LC50 (48h): 528.62; LC (96h): 101.86-113.46 mg/L) is much more restrictive than the values obtained with the read-across approach from experimental data with sodium acetate, the neutralised form of the acid (LC50 (120h): 12580 mg/L); LC50 (96h): 9440 mg/L).

Key value for chemical safety assessment:

According to the read-across approaches from experimental results with supporting substance acetic acid, the triacetoxyvinylsilane key value for chemical safety assessment is calculated to be LC50 = 101.86 mg/L (based on mortality). This value is the most restrictive and it was obtain by read-across approach from the reliable study by Mattson et.al., 1976.