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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
24 March 1961
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1961
Report Date:
1961

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Experimental design according to Everett (1956).
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
No. of animals per sex per dose:
25
Control animals:
other: not required as Scopolomanine was used as one reference substance

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 275 mg/kg bw
Based on:
test mat.
Clinical signs:
effective dose (salivation, 50% of test animals): 0.09 mg/kg bw effective dose (tremor, 50% of test animals): 0.14 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
A LD50 value of 1275 mg/kg bw in mice was reported in a publication. As the report is not sufficiently documented the reliability is not assignable.