Registration Dossier
Registration Dossier
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EC number: 210-351-3 | CAS number: 613-73-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- o-phenylenediacetonitrile
- EC Number:
- 210-351-3
- EC Name:
- o-phenylenediacetonitrile
- Cas Number:
- 613-73-0
- Molecular formula:
- C10H8N2
- IUPAC Name:
- 2-[2-(cyanomethyl)phenyl]acetonitrile
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- non-irritant
- Executive summary:
The acute dermal irritation/corrosion of \2 Phenylendiacetonitril was tested in three albino
rabbits. The substance lryas applied in a single dose of 0.5 g to a shaved dorsal area of trunk
and covered with a gauze patch and aluminium foil which was held in contact with the skin by
an occlusive dressing. Exposure duration was 4 hours. Thereafter residual substance was
removed using distilled water.
Animals were examined for mortality, clinical signs and signs of irritation response 60 minutes,
24, 48 and 72 hours after patch removal. The grading of skin reaction of EEC Guideline B.4.
was used for evaluation of dermal irritation.
There \ilere no skin alterations observed at any observation time.
No animal died or showed clinical signs in the course of testing.
According to the results of this testing 1,2 Phenylendiacetonitril is not to classify as skin
irritant substance.
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