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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
November 1989-February 1990
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trisodium 5-[[4-chloro-6-(ethylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methyl-2-sulphonatophenyl)azo]naphthalene-2,7-disulphonate
EC Number:
277-616-3
EC Name:
Trisodium 5-[[4-chloro-6-(ethylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methyl-2-sulphonatophenyl)azo]naphthalene-2,7-disulphonate
Cas Number:
73816-74-7
Molecular formula:
C28H24ClN7O10S3.3Na
IUPAC Name:
trisodium 5-[[4-chloro-6-(ethylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methyl-2-sulphonatophenyl)azo]naphthalene-2,7-disulphonate
impurity 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): Reactive Red 45:1- Physical state: red solid powder- Analytical purity: 85% (w/w)- Impurities (identity and concentrations): NaCl (CAS: 7647-14-5) 15% (w/w)- Lot/batch No.: 7010- Expiration date of the lot/batch: unlisted- Storage condition of test material: The test substance should be stored in dry room in dark in closed container at the room temperature.

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMAL- Weight at study initiation: 244-262 g

Administration / exposure

Vehicle:
water
Details on dermal exposure:
TEST MATERIAL- Amount(s) applied (volume or weight with unit): 0.5 g with water
Doses:
5.0 g

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 other: g/kg
Clinical signs:
No clinilac signs after aplication
Gross pathology:
After 14 dayas all animals were sacrificed. No macroscipical findings were found.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The substance is not absorbed in a toxic quantity.

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