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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
The toxicity of Allyl Alcohol
Author:
Dunlap MK, Kodama JK, Wellington JS, Anderson HH, Hine, CH
Year:
1958
Bibliographic source:
A.M.A. Archives of Industrial Health 18, 303-311

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Draize Test
Deviations:
not specified
Principles of method if other than guideline:
2-Propen-1-ol (0.05 ml) was instilled into the left eye of 3 male albino rabbits.
The eyes were examined after 1 hr for signs of irritation (first unstained, then after application of 5% fluorescein sodium). Further examinations were carried our at 24 hr and 48 hr and during the subsequent week.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl alcohol
EC Number:
203-470-7
EC Name:
Allyl alcohol
Cas Number:
107-18-6
Molecular formula:
C3H6O
IUPAC Name:
prop-2-en-1-ol

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
1 h
Observation period (in vivo):
1hr, 24 hr and 48 hr
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: Conjunctival erythema
Time point:
other: 1 hr
Score:
3
Max. score:
3
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 3/3 rabbits
Irritation parameter:
other: edema
Time point:
other: 1 hr
Score:
1
Max. score:
3
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 1/3 rabbits
Irritation parameter:
other: conjunctival erythema
Time point:
other: 24 h
Score:
> 4 - < 6
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 3/3 rabbits
Irritation parameter:
other: corneal opacity
Time point:
other: 24 h
Score:
> 5 - < 10
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 2/3 rabbits
Irritation parameter:
other: iris
Time point:
other: 24 h
Score:
1
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 1/3 rabbits
Irritation parameter:
other: conjunctival redness
Time point:
other: 48 h
Score:
> 2 - < 6
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 3/3 rabbits
Irritation parameter:
other: corneal opacity
Time point:
other: 48 h
Score:
5
Reversibility:
fully reversible within: 1 week
Remarks on result:
other: affecting 1/3 rabbits

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Under the conditions of this test, 2-propen-1-ol was irritating to rabbit eye producing reversible conjunctival redness, iridial injection and corneal opacity that persisted at least 48 hr post instillation.