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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16.02.-20.02.2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
yes
Remarks:
A stock solution of the test substance should be prepared in n-octanol pre-saturated with water. Because of a low solubility of the test substance in this medium, the stock solution was prepared in water pre-saturated with n-octanol.
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-0.8
Temp.:
23 °C
pH:
6.2
Conclusions:
Partition coefficient (log P) of the test substance Acid Yellow 25 determined by shake-flask method is: log Pow = -0.80 ± 0.04 (pH 6.2, 23°C)
Executive summary:

The partition coefficient of the test substance Acid Yellow 25 was determined.For determination ofpartition coefficient was used the shake-flask method.

 

The test was performed according to the shake-flask method (OECD Test Guideline 107, Partition Coefficient (n-octanol/water): Shake Flask Method, Adopted 27 July 1995).

 

Partition coefficient (log P) of the test substance Acid Yellow 25 determined by shake-flask method is:

 

log POW= - 0.80 ± 0.04 (pH 6.2, 23.0°C)

Description of key information

The partition coefficient of the test substance Acid Yellow 25 was determined. For determination ofpartition coefficient was used the shake-flask method.

The test was performed according to theshake-flask method (OECD Test Guideline 107, Partition Coefficient (n-octanol/water): Shake Flask Method, Adopted 27 July 1995).

Only one study is available. GLP study.

Klimish score 1.

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.8
at the temperature of:
23 °C

Additional information