Registration Dossier
Registration Dossier
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EC number: 276-471-3 | CAS number: 72208-21-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- currently accepted version of guideline requires a test duration of 48 h instead of 24 h
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- GLP compliance:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 100 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 31.6 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 56.2 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 37.1 mg/L
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Geometric mean between EC0 and EC100 leads to EC50 = 56.2 mg/l after 24-hour on daphnia magna. It corresponds to 37.1 mg/l of active ingredient.
- Executive summary:
Method
Daphnia magna, exposed for 24 hours and observed for immobilisation according to OECD guideline 202 (1984).
Results
EC0 = 31.6 mg/l and EC100 = 100 mg/l. Geometric mean gives EC50 = 56.2 mg/l, equivalent to 37.1 mg/l of active ingredient.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- currently accepted version of guideline requires a test duration of 48 h instead of 24 h
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- GLP compliance:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 56.2 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 37.1 mg/L
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on mobility of daphnia magna upon 24-hour exposure, EC50 = 56.2 mg/l, equivalent to 37.1 mg/l of active ingredient.
- Executive summary:
Method
Daphnia magna, exposed for 24 hours and observed for immobilisation according to OECD guideline 202 (1984).
Results
EC50 = 56.2 mg/l, equivalent to 37.1 mg/l of active ingredient.
Referenceopen allclose all
Description of key information
EC50 (24h) = 37.1 mg/l of active ingredient on daphnia magna.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 37.1 mg/L
Additional information
Acute toxicity to daphnia magna was evaluated upon a 24-hour exposure, based on OECD guideline 202 (1984). Current version of this guideline (2004) would require a 48-hour exposure. However, this result gave a qualitative indication of the toxicity of the test substance.
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