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Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to
OECD Guideline 105 (Water Solubility)
GLP compliance:
Type of method:
flask method
Water solubility:
ca. 51.82 g/L
20 °C
ca. 2.49
Remarks on result:
other: pH of satured solution
Details on results:
Preliminary solubility result
Reference samples and extract were first measured in the range 190 / 800 nm, so as to choose the right wavelength for quantitative measurements. Since absorbance of the test solution kept the same proportions along the UV and visible spectra, preliminary test result was considered for the final results calculations. Wavelength chosen was 514.00 nm.

Test results
Reference solutions were measured in the spectrophotometer in quantitative mode, thus generating a calibration curve. Calibration curve was smooth and linear at every concentration. Considering that preliminary test resulted in an absorbance keeping the same shape like the references, its value was considered for the 24 hours’ measurement (test 1).

Adjusting concentrations in proportion to the real weights, the folllowing results were obtained:

test 1 (24 hs) 50.36 g/l
test 2 (48 hs) 50.72 g/l
test 3 (96 hs) 57.37 g/l
average solubility 51.82 g/l
standard deviation 2.22
pH mother solution 2.99
pH satured solution 2.49
At 20 °C and pH 2.49, the substance is very soluble in water, namely 51.82 g/l.
Executive summary:


Shake flask method was used. A first preliminary solution was prepared, equilibrated at 30 °C for 24 h, then cooled to 20 °C for 24 hs. A second and third solutions were prepared and equilibrated at 30 °C for 48 and 96 hs, respectively. Then these solutions were cooled down to 20 °C for 24 hs. After centrifugation, analysis by UV-vis spectrophotometer was performed.


Average water solubility was 51.82 g/l at 20 °C and pH 2.49 (satured solution).

Description of key information

Water solubility is 51.82 g/l at 20 °C and pH 2.49 (satured solution).

Key value for chemical safety assessment

Water solubility:
51.82 g/L
at the temperature of:
20 °C

Additional information

OECD guideline 105.