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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 19, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
other: UV-Vis spectrophotometer
Type:
Pow
Partition coefficient:
ca. 0.863
Temp.:
20 °C
pH:
ca. 6.32
Remarks on result:
other: Std. dev. Pow 0.0935
Type:
log Pow
Partition coefficient:
ca. -0.066
Temp.:
20 °C
pH:
ca. 6.32
Remarks on result:
other: Std. dev. log Pow 0.047
Conclusions:
Pow = 0.8634
LogPow = -0.0658
Executive summary:

Method

Partition coefficient was determined by means of shake flask method as per recommendations of OECD Guideline 107. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.

Result

Study conducted at 20 °C and at pH of 6.32.

The average Pow is 0.8634

The average logPow is -0.0658

Description of key information

LogPow = -0.0658 at 20 °C and pH = 6.32

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.066
at the temperature of:
20 °C

Additional information

Partition coefficient was determined by means of shake flask method as per recommendations of OECD Guideline 107. Partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting in two largely immiscible solvents.