Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Guidance Document for using the OECD (Q)SAR Application Toolbox to develop Chemical Categories according to the OECD Guidance on Grouping of Chemicals
Author:
OECD Environment, Health and Safety Publications
Year:
2009
Bibliographic source:
Series on Testing and Assessment No. 102

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD QSAR Toolbox 4.1

Test material

Constituent 1
Chemical structure
Reference substance name:
[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
EC Number:
201-036-1
EC Name:
[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
Cas Number:
77-54-3
Molecular formula:
C17H28O2
IUPAC Name:
[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
LOEL
Effect level:
ca. 55.8 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
clinical signs

Results: F1 generation

Effect levels (F1)

Dose descriptor:
LOEL
Generation:
F1
Effect level:
ca. 55.8 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
clinical signs

Overall reproductive toxicity

Reproductive effects observed:
no

Any other information on results incl. tables

Predicted endpoint: LOEL, NOAEL; No effect specified; Oryctolagus cuniculus, Rabbit, Rat, Rattus

norvegicus; No duration specified; No guideline specified

Predicted value: 55.8   (from 2.16 to 1.44E+03)

Unit/scale: mg/kg bdwt/d

Data gap filling method: Read-across analysis

Applicant's summary and conclusion