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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Non-GLP guideline study without anayltical monitoring
Justification for type of information:
REPORTING FORMAT FOR THE CATEGORY APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The read across follows Scenario 5 - Qualitatively and quantitatively similar effects are caused by a common compound, which is formed from all category members (as described in the 2017 Read-Across Assessment Framework document).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
TARGET: Reaction Mass of 4-sulphophthalic acid and 3-sulphophthalic acid (ratio 3:1)
SOURCE: Sulfophthalic acid sodium and ammonium salts
3. CATEGORY APPROACH JUSTIFICATION
Sulphophthalic acid sodium and ammonium salts are different organic salts of a common acid, sulphophthalic acid. The salts dissociate rapidly in the medium (water) to the common sulphophthalic acid anion and to their different counter ions. The counter ions ammonium and sodium do not influence the solubility and the toxicity of the category members.
4. DATA MATRIX
See Read Across document attached to CSR
Qualifier:
according to
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
18.9-20.8 °C
pH:
3.39-8.16
Dissolved oxygen:
7.6 - 9.3 mg/l
Nominal and measured concentrations:
Nominal test concentrations (mg/L):
Details on test conditions:
TEST SYSTEM
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
Key result
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
62.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
88.39 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: 88.39-88.39 mg/l 95% CL
Key result
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
125 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Executive summary:

There are no short-term toxicity to aquatic invertebrates studies on the reaction mass of 4-sulphophthalic acid and 3-sulphophthalic acid (target substance). However, data is available for the reaction mass of 1,2-benzenedicarboxylic acid, 4-sulfo-, trisodium salt, 1,2-benzenedicarboxylic acid, 3-sulfo-, sodium salt (1:3), sodium sulphate (source substance) and it was used for read-across purposes (BASF AG, 1987).

The acute toxicity of the source substance onDaphnia magnawas studied under static conditions. Daphnids were exposed to control and test chemical at nominal concentrations of 100, 300 and 1000 mg/L water accommodated factor (WAF) for 48 hours. Mortality, immobilisation and sub-lethal effects were observed daily. The 48 hr-EC0, EC50, EC100were 62.5, 88.39 and 125 mg/L, respectively.

Description of key information

There are no short-term toxicity to aquatic invertebrate studies on the reaction mass of 4-sulphophthalic acid and 3-sulphophthalic acid (read across target substance). However, data is available for the reaction mass of 1,2-benzenedicarboxylic acid, 4-sulfo-, trisodium salt, 1,2-benzenedicarboxylic acid, 3-sulfo-, sodium salt (1:3), sodium sulphate (ead across source substance) and it was used for read-across purposes.

The acute toxicity of the source substance on Daphnia magna was studied under static conditions. Daphnids were exposed to control and test chemical at nominal concentrations of 100, 300 and 1000 mg/L water accommodated factor (WAF) for 48 hours. Mortality, immobilisation and sub-lethal effects were observed daily. The 48 hr-EC0, EC50, EC100were 62.5, 88.39 and 125 mg/L, respectively.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
88.39 mg/L

Additional information