Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08-Dec-2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.46
- Temp.:
- 23.3 °C
- Remarks on result:
- other: Temperature of HPLC column
- Conclusions:
- A log Pow of 3.46 (at 23.3 °C) was determined for the test substance according to EU Method A.8.
- Executive summary:
The study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine the partition coefficient of the test substance. Using the HPLC method partition coefficient Pow was determined to be 3.46 at 23.3 °C. The determination was performed at 23.3 °C, but the values obtained can be considered to represent the values at ambient temperature. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Reference
Results of Test Item Analysis
The table shows the retention time data and calculated log k values for the test item. Two individual log Pow values were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values.
Retention Times, Capacity Factors and Partition Coefficients
|
tR(min) |
k |
Log k |
Log Pow |
|
|
|
|
1stcalibration |
2ndcalibration |
|
6.367 |
10.3 |
1.01 |
3.46 ± 0.06 3.31 to 3.62 (95 % CI) |
3.46 ± 0.06 3.29 to 3.62 (95 % CI) |
|
Mean |
6.380 |
10.3 |
1.01 |
||
|
6.374 |
10.3 |
1.01 |
3.46 |
|
tR: Retention time
k: Capacity factor test item
Pow: Partition Coefficient (n-octanol / water)
CI : Confidence Interval
Conclusions
Two individual log Pow values for the test item were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values.
Based on these data a log Pow of 3.46 for the test item was determined.
Description of key information
Log Pow: 3.46 at 23.3 °C (EU Method A.8., HPLC method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.46
- at the temperature of:
- 23.3 °C
Additional information
A study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine the partition coefficient of the test substance. Using the HPLC method partition coefficient Pow was determined to be 3.46 at 23.3 °C. The determination was performed at 23.3 °C, but the values obtained can be considered to represent the values at ambient temperature. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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