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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08.12-16.12.2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
76.42 mg/L
Conc. based on:
test mat.
Incubation duration:
3 d
Temp.:
20 °C
pH:
> 5.88 - < 5.91

Table No.4: Results of determination of test substance solubility in water by flask method

 

Day

pH of saturated solution

1stinjection

(mg/L)

2ndinjection

(mg/L)

Average of 1stand 2ndinj.

(mg/L)

1st

5.88

76.41

76.44

76.4

2nd

5.91

76.92

76.91

76.9

3rd

5.90

75.95

75.91

75.9

Overall Mean

76.42

SD

0.49

RSD (%)

0.64

Conclusions:
The water solubility of the test substance, Methylcentralit, established by the flask method is 76.42 mg/L.
Executive summary:

Water solubility test was performed for the test substance, Methylcentralit. Flask method was used.

Test was performed according to the Method A.6., Water Solubility, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

The water solubility of the test substance, Methylcentralit, established by the flask method is 76.42 mg/L.

Description of key information

Only one study is available.

Method A.6., Water Solubility, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

GLP study.

Klimish score 1.

The water solubility of the test substance, Methylcentralit, established by the flask method is 76.42 mg/L.

Key value for chemical safety assessment

Water solubility:
76.42 mg/L
at the temperature of:
20 °C

Additional information