Registration Dossier
Registration Dossier
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EC number: 946-056-8 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Daphnia magna (OECD 211).
Key value for chemical safety assessment
Additional information
One study investigating the chronic toxicity of the target substance Fatty acids, Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) to Daphnia magna is available. This test was conducted with a semi-static design according to OECD guideline 211 under GLP conditions und exposed to the following test item concentrations: Control, 1.0, 3.2, 10, 32 and 100 µg/L (nominal) and was 0.19, 0.19, 1.1, 12 and 56 µg/L (average measured). Due to the low solubility of the test item dimethylformamide (DMF) was used as a solvent. The renewal rate of the test item concentrations were every day and the test duration was 21 d. Samples were taken from test solutions at test start and test end of four intervals 24 hours nominal days 0-1, 6-7, 13-14 and 20-21) as well as from stock solutions on days 0, 6, 13 and 20. During the study samples for analyses were taken at the beginning and the end of four renewal intervals. Measured concentrations decreased during the 24-hour renewal periods. Results were consequently based on average measured concentrations over the 21-day test period. Hexanedioic acid, di-C16-18 alkyl esters did not affect reproduction of Daphnia magna at average exposure concentration of 56 µg/L after 21 days of exposure (NOEC). It should be noted that this concentration exceeded the water solubility of < 0.05 mg/L. Thus, no chronic effects of the substance to aquatic invertebrates up to the limit of water solubility are expected.
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