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EC number: 278-503-1
CAS number: 76622-74-7
EC50 (48 h) = 0.43 mg/L (measured, geometric mean, OECD 202, D. magna),
There is no study available investigating the short-term toxicity
of Potassium (Z)-N-methyl-N-(1-oxo-9-octadecenyl) aminoacetate (CAS
76622-74-7) to aquatic invertebrates. Therefore, read-across was
conducted to the related source substances
(Z)-N-methyl-N-(1-oxo-9-octadecenyl)glycine (CAS 110-25-8) and Sodium
N-methyl-N-(1-oxo-9-octadecenyl)aminoacetate (CAS 3624-77-9) in
accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. Based on the
high degree of similarity between the structural and physico-chemical
properties of the target and source substances, the source substances
are considered suitable representatives for the assessment of the
short-term toxicity of the target substance to aquatic invertebrates.
The read-across approach is justified in detail within the analogue
justification in IUCLID section 13.
Three studies are available of which two studies investigated the
acute toxicity of (Z)-N-methyl-N-(1-oxo-9-octadecenyl)glycine (CAS
110-25-8) to aquatic invertebrates.
In the first study, conducted according to the OECD guideline 202
and GLP with the source substance
Z)-N-methyl-N-(1-oxo-9-octadecenyl)glycine (CAS 110-25-8), D. magna was
exposed to the nominal concentrations of 0.1, 0.22, 0.46, 1.0, 2.2, 4.6,
10, 22, 46, and 100 mg/L (for 48 h under static conditions. Test item
concentrations were analytically verified by HPLC at the beginning and
end of the test. In treatments < 1 mg/L no test item could be analyzed
after 48 h. The recovery after 48 h for treatments 1 – 100 mg/L was in
the range of 44 – 128% of the nominal concentrations. Therefore, the
determination of the biological results was based on the mean measured
concentration for the test concentrations 1 – 100 mg/L and on the
initial measured concentration for the test concentration 0.46 mg/L.
After 48 h, an EC50 of 0.43 mg/L (geometric mean measured) was obtained.
In the second study conducted according to EU method C.2 with the
substance (Z)-N-methyl-N-(1-oxo-9-octadecenyl)glycine (CAS 110-25-8), D.
magna was exposed to 0.098, 0.195, 0.39, 0.781, 1.56, 3.12, 6.25, 12.5,
25.0, and 50.0 mg/L nominal test item concentrations for 48 h under
static conditions. Tween 80 was used as vehicle at equal concentrations
as the test item at every treatment level. The test item concentrations
were not analytically verified. The obtained EC50 after 48 h was 0.53
In the third study conducted according to OECD 202 and GLP with
the substance Sodium N-methyl-N-(1-oxo-9-octadecenyl)aminoacetate (CAS
3624-77-9), D. magna was exposed to 0.5, 1.0, 2.5, 5.0, 10, and 25 mg/L
test item for 48 h under static conditions. The test item concentrations
were not analytically verified. The reported EC50 (48 h) is 1.4 mg/L
Based on the available results from the structurally related
source substances (in accordance with Regulation (EC) No 1907/2006 Annex
XI, 1.5), which are characterized by a similar ecotoxicological profile
and comparable structure, an EC50 (48 h) of 0.43 mg/L (geom. mean
measured) is retained as effect concentration for the acute toxicity of
the target substance Potassium (Z)-N-methyl-N-(1-oxo-9-octadecenyl)
aminoacetate (CAS 76622-74-7) to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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