Registration Dossier
Registration Dossier
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EC number: 246-922-9 | CAS number: 25378-22-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A measured BCF is not available for dodecene. Log BCF have been calculated on the basis of a log Kow of 6.02 using two QSAR. Calculated log BCF range from 2.26-4.53.
Key value for chemical safety assessment
Additional information
A measured BCF is not available for dodecene. As the calculated log Kow of dodecene is >3 the bioaccumulation endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7c Endpoint Specific Guidance (2008) indicates that before commissioning a new vertebrate test alternative sources of data on the bioaccumulation potential of a chemical should be used.
Nonpolar substances have been shown to have a linear relationship between log Kow and BCF in the log Kow range 1 -6. However, at log Kow >6 a decreasing relationship is observed. Several QSAR have been developed that calculate the BCF of non-polar, hydrophobic compounds on the basis of their log Kow (e.g. Connell and Hawker, 1988 and USEPA, 2008). Dodecene falls within the applicability domain of these models. The calculated log BCF range from 2.26 -4.53, indicating that dodecene may bioaccumulate or pose a risk of secondary poisoning.
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